Human Gene CRISPLD2 (uc002fin.2) Description and Page Index
  Description: cysteine-rich secretory protein LCCL domain
Transcript (Including UTRs)
   Position: hg18 chr16:83,411,113-83,471,831 Size: 60,719 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg18 chr16:83,429,603-83,471,736 Size: 42,134 Coding Exon Count: 12 

Page IndexSequence and LinksGenetic AssociationsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2009-03-03

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:83,411,113-83,471,831)mRNA (may differ from genome)Protein (449 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHuGEMGIOMIM
PubMedReactomeStanford SOURCETreefamUniProtKB

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CRISPLD2
CDC HuGE Published Literature: CRISPLD2

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -85.40202-0.423 Picture PostScript Text
3' UTR -16.4695-0.173 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF03815 - LCCL domain
PF00188 - SCP-like extracellular protein

ModBase Predicted Comparative 3D Structure on Q9H0B8-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
     SGD
     Protein Sequence
     Alignment

-  Descriptions from all associated GenBank mRNAs
  AY358790 - Homo sapiens clone DNA131590 trypsin inhibitor (UNQ2914) mRNA, complete cds.
AK303887 - Homo sapiens cDNA FLJ61040 complete cds, moderately similar to Homo sapiens cysteine-rich secretory protein LCCL domain containing 2 (CRISPLD2), mRNA.
AL136861 - Homo sapiens mRNA; cDNA DKFZp434B044 (from clone DKFZp434B044).
AB587512 - Synthetic construct DNA, clone: pF1KE0001, Homo sapiens CRISPLD2 gene for cysteine-rich secretory protein LCCL domain containing 2, without stop codon, in Flexi system.
AM393137 - Synthetic construct Homo sapiens clone IMAGE:100001654 for hypothetical protein (CRISPLD2 gene).
HM005620 - Homo sapiens clone HTL-S-207a testis secretory sperm-binding protein Li 207a mRNA, complete cds.
LF384477 - JP 2014500723-A/191980: Polycomb-Associated Non-Coding RNAs.
MA620054 - JP 2018138019-A/191980: Polycomb-Associated Non-Coding RNAs.
AK308396 - Homo sapiens cDNA, FLJ98344.
AY358413 - Homo sapiens clone DNA59853 trypsin inhibitor (UNQ2914) mRNA, complete cds.
BC063012 - Homo sapiens cysteine-rich secretory protein LCCL domain containing 2, mRNA (cDNA clone MGC:74865 IMAGE:5217820), complete cds.
BC007689 - Homo sapiens cysteine-rich secretory protein LCCL domain containing 2, mRNA (cDNA clone IMAGE:3953885), complete cds.
AK027395 - Homo sapiens cDNA FLJ14489 fis, clone MAMMA1002881, weakly similar to GLIOMA PATHOGENESIS-RELATED PROTEIN.
CU687626 - Synthetic construct Homo sapiens gateway clone IMAGE:100021782 5' read CRISPLD2 mRNA.
JD464950 - Sequence 445974 from Patent EP1572962.
JD523704 - Sequence 504728 from Patent EP1572962.
KJ903358 - Synthetic construct Homo sapiens clone ccsbBroadEn_12752 CRISPLD2 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H0B8 (Reactome details) participates in the following event(s):

R-HSA-6800434 Exocytosis of ficolin-rich granule lumen proteins
R-HSA-6798748 Exocytosis of secretory granule lumen proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: BC063012, CRISP11, LCRISP2, NM_031476, NP_113664, Q9H0B8-2, uc002fin.1, UNQ2914/PRO1156/PRO9783
UCSC ID: uc002fin.2
RefSeq Accession: NM_031476
Protein: Q9H0B8-2, splice isoform of Q9H0B8

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC063012.1
exon count: 13CDS single in 3' UTR: no RNA size: 1710
ORF size: 1350CDS single in intron: no Alignment % ID: 99.70
txCdsPredict score: 2896.00frame shift in genome: no % Coverage: 96.32
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 140# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.