Human Gene IL17C (uc002fla.3) Description and Page Index
Description: Homo sapiens interleukin 17C (IL17C), mRNA. RefSeq Summary (NM_013278): The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358471.1, AF152099.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2163459 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr16:88,705,001-88,706,882 Size: 1,882 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr16:88,705,050-88,706,480 Size: 1,431 Coding Exon Count: 3
ID:IL17C_HUMAN DESCRIPTION: RecName: Full=Interleukin-17C; Short=IL-17C; AltName: Full=Cytokine CX2; Flags: Precursor; FUNCTION: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the IL-17 family. WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry; URL="http://en.wikipedia.org/wiki/Interleukin_17";
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): IL17C CDC HuGE Published Literature: IL17C
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P0M4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.