Human Gene IL17C (uc002fla.3) Description and Page Index
  Description: Homo sapiens interleukin 17C (IL17C), mRNA.
RefSeq Summary (NM_013278): The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358471.1, AF152099.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2163459 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000244241.5/ ENSP00000244241.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr16:88,705,001-88,706,882 Size: 1,882 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr16:88,705,050-88,706,480 Size: 1,431 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:88,705,001-88,706,882)mRNA (may differ from genome)Protein (197 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Interleukin-17C; Short=IL-17C; AltName: Full=Cytokine CX2; Flags: Precursor;
FUNCTION: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
SIMILARITY: Belongs to the IL-17 family.
WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry; URL="";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): IL17C
CDC HuGE Published Literature: IL17C

-  MalaCards Disease Associations
  MalaCards Gene Search: IL17C
Diseases sorted by gene-association score: amyotrophic lateral sclerosis 1 (0)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.64 RPKM in Testis
Total median expression: 2.94 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.2049-0.351 Picture PostScript Text
3' UTR -132.50402-0.330 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010345 - Interleukin-17
IPR020440 - Interleukin-17_chordata

Pfam Domains:
PF06083 - Interleukin-17

SCOP Domains:
57501 - Cystine-knot cytokines

ModBase Predicted Comparative 3D Structure on Q9P0M4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity

Biological Process:
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0010469 regulation of receptor activity
GO:0097400 interleukin-17-mediated signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space

-  Descriptions from all associated GenBank mRNAs
  BC069410 - Homo sapiens cDNA clone IMAGE:7262201, with apparent retained intron.
AF152099 - Homo sapiens interleukin 17C mRNA, complete cds.
AY358471 - Homo sapiens clone DNA62377 IL17C (UNQ561) mRNA, complete cds.
LF384484 - JP 2014500723-A/191987: Polycomb-Associated Non-Coding RNAs.
BC101835 - Homo sapiens interleukin 17C, mRNA (cDNA clone MGC:126884 IMAGE:8069341), complete cds.
BC112196 - Homo sapiens interleukin 17C, mRNA (cDNA clone MGC:138401 IMAGE:8327664), complete cds.
AF142410 - Homo sapiens cytokine CX2 precusor mRNA, complete cds.
BC069152 - Homo sapiens interleukin 17C, mRNA (cDNA clone MGC:95437 IMAGE:7217012), complete cds.
JD399978 - Sequence 381002 from Patent EP1572962.
JD144898 - Sequence 125922 from Patent EP1572962.
JD428139 - Sequence 409163 from Patent EP1572962.
JD148118 - Sequence 129142 from Patent EP1572962.
JD370034 - Sequence 351058 from Patent EP1572962.
JD137191 - Sequence 118215 from Patent EP1572962.
JD102242 - Sequence 83266 from Patent EP1572962.
JD160330 - Sequence 141354 from Patent EP1572962.
JD393854 - Sequence 374878 from Patent EP1572962.
JD075693 - Sequence 56717 from Patent EP1572962.
MA620061 - JP 2018138019-A/191987: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9P0M4 (Reactome details) participates in the following event(s):

R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: IL17C_HUMAN, NM_013278, NP_037410, Q3MIG8, Q9HC75, Q9P0M4, UNQ561/PRO1122
UCSC ID: uc002fla.3
RefSeq Accession: NM_013278
Protein: Q9P0M4 (aka IL17C_HUMAN or I17C_HUMAN)
CCDS: CCDS42217.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_013278.3
exon count: 3CDS single in 3' UTR: no RNA size: 1048
ORF size: 594CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1388.00frame shift in genome: no % Coverage: 99.71
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.