Human Gene IL17C (uc002fla.3) Description and Page Index
Description: Homo sapiens interleukin 17C (IL17C), mRNA. RefSeq Summary (NM_013278): The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358471.1, AF152099.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2163459 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000244241.5/ ENSP00000244241.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr16:88,705,001-88,706,882 Size: 1,882 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr16:88,705,050-88,706,480 Size: 1,431 Coding Exon Count: 3
ID:IL17C_HUMAN DESCRIPTION: RecName: Full=Interleukin-17C; Short=IL-17C; AltName: Full=Cytokine CX2; Flags: Precursor; FUNCTION: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the IL-17 family. WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry; URL="http://en.wikipedia.org/wiki/Interleukin_17";
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): IL17C CDC HuGE Published Literature: IL17C
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P0M4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.