Human Gene RNF166 (uc002flk.3) Description and Page Index
  Description: Homo sapiens ring finger protein 166 (RNF166), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:88,762,903-88,772,829 Size: 9,927 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr16:88,763,976-88,772,733 Size: 8,758 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:88,762,903-88,772,829)mRNA (may differ from genome)Protein (237 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=RING finger protein 166;
SIMILARITY: Contains 1 RING-type zinc finger.
SIMILARITY: Contains 1 UIM (ubiquitin-interacting motif) repeat.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.86 RPKM in Whole Blood
Total median expression: 354.99 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.9096-0.489 Picture PostScript Text
3' UTR -466.801073-0.435 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008598 - Di19_RING_finger_144
IPR015880 - Znf_C2H2-like
IPR001841 - Znf_RING
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00097 - Zinc finger, C3HC4 type (RING finger)
PF02809 - Ubiquitin interaction motif
PF05605 - Drought induced 19 protein (Di19), zinc-binding
PF13445 - RING-type zinc-finger
PF13639 - Ring finger domain
PF13920 - Zinc finger, C3HC4 type (RING finger)
PF13923 - Zinc finger, C3HC4 type (RING finger)
PF14634 - zinc-RING finger domain

SCOP Domains:
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q96A37
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0031624 ubiquitin conjugating enzyme binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity

Biological Process:
GO:0000209 protein polyubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Cellular Component:
GO:0005622 intracellular

-  Descriptions from all associated GenBank mRNAs
  LF208346 - JP 2014500723-A/15849: Polycomb-Associated Non-Coding RNAs.
LF384488 - JP 2014500723-A/191991: Polycomb-Associated Non-Coding RNAs.
AK026860 - Homo sapiens cDNA: FLJ23207 fis, clone ADSE00968.
BC017226 - Homo sapiens ring finger protein 166, mRNA (cDNA clone MGC:14381 IMAGE:4299817), complete cds.
AK057201 - Homo sapiens cDNA FLJ32639 fis, clone SYNOV2001014, weakly similar to Mus musculus Zfp228 (Znf228) mRNA.
AK057106 - Homo sapiens cDNA FLJ32544 fis, clone SMINT2000545, highly similar to RING finger protein 166.
JD387216 - Sequence 368240 from Patent EP1572962.
JD271617 - Sequence 252641 from Patent EP1572962.
JD054396 - Sequence 35420 from Patent EP1572962.
JD467391 - Sequence 448415 from Patent EP1572962.
JD424330 - Sequence 405354 from Patent EP1572962.
JD335032 - Sequence 316056 from Patent EP1572962.
JD454144 - Sequence 435168 from Patent EP1572962.
LF375077 - JP 2014500723-A/182580: Polycomb-Associated Non-Coding RNAs.
BC013948 - Homo sapiens ring finger protein 166, mRNA (cDNA clone MGC:2647 IMAGE:3509621), complete cds.
LF375078 - JP 2014500723-A/182581: Polycomb-Associated Non-Coding RNAs.
JD101127 - Sequence 82151 from Patent EP1572962.
AK290920 - Homo sapiens cDNA FLJ76164 complete cds, highly similar to Homo sapiens ring finger protein 166 (RNF166), mRNA.
JD400566 - Sequence 381590 from Patent EP1572962.
JD277846 - Sequence 258870 from Patent EP1572962.
JD321503 - Sequence 302527 from Patent EP1572962.
JD427735 - Sequence 408759 from Patent EP1572962.
HQ258016 - Synthetic construct Homo sapiens clone IMAGE:100072325 ring finger protein 166 (RNF166) gene, encodes complete protein.
KJ900031 - Synthetic construct Homo sapiens clone ccsbBroadEn_09425 RNF166 gene, encodes complete protein.
KJ900032 - Synthetic construct Homo sapiens clone ccsbBroadEn_09426 RNF166 gene, encodes complete protein.
CU680704 - Synthetic construct Homo sapiens gateway clone IMAGE:100023209 5' read RNF166 mRNA.
MA620065 - JP 2018138019-A/191991: Polycomb-Associated Non-Coding RNAs.
MA443923 - JP 2018138019-A/15849: Polycomb-Associated Non-Coding RNAs.
MA610654 - JP 2018138019-A/182580: Polycomb-Associated Non-Coding RNAs.
MA610655 - JP 2018138019-A/182581: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KQ03, D3DX75, NM_178841, NP_001165287, Q96A37, Q96DM0, RN166_HUMAN
UCSC ID: uc002flk.3
RefSeq Accession: NM_178841
Protein: Q96A37 (aka RN166_HUMAN)
CCDS: CCDS10969.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_178841.3
exon count: 6CDS single in 3' UTR: no RNA size: 1888
ORF size: 714CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 1484.00frame shift in genome: no % Coverage: 99.74
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.