Human Gene TAX1BP3 (ENST00000225525.4) from GENCODE V44
  Description: Homo sapiens Tax1 binding protein 3 (TAX1BP3), transcript variant 1, mRNA. (from RefSeq NM_014604)
RefSeq Summary (NM_014604): This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017].
Gencode Transcript: ENST00000225525.4
Gencode Gene: ENSG00000213977.8
Transcript (Including UTRs)
   Position: hg38 chr17:3,662,895-3,668,578 Size: 5,684 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr17:3,663,748-3,668,526 Size: 4,779 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:3,662,895-3,668,578)mRNA (may differ from genome)Protein (124 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TX1B3_HUMAN
DESCRIPTION: RecName: Full=Tax1-binding protein 3; AltName: Full=Glutaminase-interacting protein 3; AltName: Full=Tax interaction protein 1; Short=TIP-1; AltName: Full=Tax-interacting protein 1;
FUNCTION: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.
SUBUNIT: Interacts (via its PDZ domain) with GLS2. Interacts (via its PDZ domain) with RTKN (via the C-terminal region); this interaction facilitates Rho-mediated activation of the FOS serum response element (SRE). Interacts (via its PDZ domain) with CTNNB1; this interaction inhibits the transcriptional activity of CTNNB1. Interacts with HTLV-1 TAX protein. Interacts (via PDZ domain) with ARHGEF16. Interacts (via PDZ domain) with KCNJ4 (via C-terminus). Competes with LIN7A for KCNJ4 binding.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the cell membrane by interaction with membrane proteins.
TISSUE SPECIFICITY: Ubiquitous. Detected in brain, heart, kidney, lung, small intestine and skeletal muscle. Detected in various cell lines including HeLa. Weakly expressed in peripheral blood leukocytes.
SIMILARITY: Contains 1 PDZ (DHR) domain.
SEQUENCE CAUTION: Sequence=AAF43104.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TAX1BP3
Diseases sorted by gene-association score: cholesterol embolism (16), intracranial embolism (9), cystinosis (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 70.84 RPKM in Nerve - Tibial
Total median expression: 1350.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.1052-0.444 Picture PostScript Text
3' UTR -325.20853-0.381 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001478 - PDZ
IPR017268 - Tax1-binding_p3

Pfam Domains:
PF00595 - PDZ domain (Also known as DHR or GLGF)

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2KG2 - NMR MuPIT 2L4S - NMR MuPIT 2L4T - NMR MuPIT 2VZ5 - X-ray MuPIT 3GJ9 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on O14907
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGI EnsemblEnsemblWormBase 
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence 
AlignmentAlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding

Biological Process:
GO:0007266 Rho protein signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0090630 activation of GTPase activity
GO:2000009 negative regulation of protein localization to cell surface

Cellular Component:
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AB209623 - Homo sapiens mRNA for purinergic receptor P2X5 isoform A variant protein.
JD230820 - Sequence 211844 from Patent EP1572962.
JD231850 - Sequence 212874 from Patent EP1572962.
U90913 - Human clone 23665 mRNA sequence.
AF234997 - Homo sapiens glutaminase-interacting protein 3 mRNA, complete cds.
AF028823 - Homo sapiens Tax interaction protein 1 mRNA, complete cds.
AF277318 - Homo sapiens tax-interacting protein 1 mRNA, complete cds.
BC023980 - Homo sapiens Tax1 (human T-cell leukemia virus type I) binding protein 3, mRNA (cDNA clone MGC:22712 IMAGE:4069168), complete cds.
JD337799 - Sequence 318823 from Patent EP1572962.
JD190494 - Sequence 171518 from Patent EP1572962.
JD096979 - Sequence 78003 from Patent EP1572962.
AK001327 - Homo sapiens cDNA FLJ10465 fis, clone NT2RP1001616.
JD131078 - Sequence 112102 from Patent EP1572962.
JD344584 - Sequence 325608 from Patent EP1572962.
JD139063 - Sequence 120087 from Patent EP1572962.
JD419345 - Sequence 400369 from Patent EP1572962.
JD114788 - Sequence 95812 from Patent EP1572962.
JD232424 - Sequence 213448 from Patent EP1572962.
JD323971 - Sequence 304995 from Patent EP1572962.
JD463591 - Sequence 444615 from Patent EP1572962.
JD225746 - Sequence 206770 from Patent EP1572962.
JD168062 - Sequence 149086 from Patent EP1572962.
JD520057 - Sequence 501081 from Patent EP1572962.
JD163805 - Sequence 144829 from Patent EP1572962.
JD163280 - Sequence 144304 from Patent EP1572962.
JD193326 - Sequence 174350 from Patent EP1572962.
JD255220 - Sequence 236244 from Patent EP1572962.
JD137884 - Sequence 118908 from Patent EP1572962.
JD115619 - Sequence 96643 from Patent EP1572962.
JD334347 - Sequence 315371 from Patent EP1572962.
AK315408 - Homo sapiens cDNA, FLJ96457, Homo sapiens Tax interaction protein 1 (TIP-1), mRNA.
HQ447711 - Synthetic construct Homo sapiens clone IMAGE:100071041; CCSB012799_01 Tax1 (human T-cell leukemia virus type I) binding protein 3 (TAX1BP3) gene, encodes complete protein.
KJ898777 - Synthetic construct Homo sapiens clone ccsbBroadEn_08171 TAX1BP3 gene, encodes complete protein.
AB590842 - Synthetic construct DNA, clone: pFN21AE2175, Homo sapiens TAX1BP3 gene for Tax1 (human T-cell leukemia virus type I) binding protein 3, without stop codon, in Flexi system.
CU692828 - Synthetic construct Homo sapiens gateway clone IMAGE:100021850 5' read TAX1BP3 mRNA.
BC035653 - Homo sapiens Tax1 (human T-cell leukemia virus type I) binding protein 3, mRNA (cDNA clone IMAGE:5587663), **** WARNING: chimeric clone ****.
JD470806 - Sequence 451830 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_tidPathway - Chaperones modulate interferon Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein O14907 (Reactome details) participates in the following event(s):

R-HSA-5666216 RHOA:GTP:RTKN binds TAX1BP3
R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins
R-HSA-195258 RHO GTPase Effectors
R-HSA-194315 Signaling by Rho GTPases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2RD53, D3DTJ6, ENST00000225525.1, ENST00000225525.2, ENST00000225525.3, NM_014604, O14907, Q7LCQ4, TIP1, TX1B3_HUMAN, uc002fwc.1, uc002fwc.2, uc002fwc.3, uc002fwc.4, uc002fwc.5
UCSC ID: ENST00000225525.4
RefSeq Accession: NM_014604
Protein: O14907 (aka TX1B3_HUMAN)
CCDS: CCDS11032.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.