Human Gene CAMTA2 (ENST00000381311.9) from GENCODE V44
Description: Homo sapiens calmodulin binding transcription activator 2 (CAMTA2), transcript variant 2, mRNA. (from RefSeq NM_001171166) RefSeq Summary (NM_001171166): The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]. Gencode Transcript: ENST00000381311.9 Gencode Gene: ENSG00000108509.21 Transcript (Including UTRs) Position: hg38 chr17:4,967,997-4,987,650 Size: 19,654 Total Exon Count: 21 Strand: - Coding Region Position: hg38 chr17:4,968,756-4,987,629 Size: 18,874 Coding Exon Count: 21
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O94983
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0005515 protein binding GO:0008134 transcription factor binding GO:0042826 histone deacetylase binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0014898 cardiac muscle hypertrophy in response to stress GO:0045944 positive regulation of transcription from RNA polymerase II promoter
US Server
