ID:RHG44_HUMAN DESCRIPTION: RecName: Full=Rho GTPase-activating protein 44; AltName: Full=NPC-A-10; AltName: Full=Rho-type GTPase-activating protein RICH2; AltName: Full=RhoGAP interacting with CIP4 homologs protein 2; Short=RICH-2; FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1. SUBUNIT: Interacts with BST2 (via cytoplasmic domain). TISSUE SPECIFICITY: Highly expressed in brain. Expressed at weak level in other tissues. SIMILARITY: Contains 1 BAR domain. SIMILARITY: Contains 1 Rho-GAP domain. SEQUENCE CAUTION: Sequence=AAP73805.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAP73805.1; Type=Frameshift; Positions=385; Sequence=BAA31647.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03114 - BAR domain PF00620 - RhoGAP domain
ModBase Predicted Comparative 3D Structure on Q17R89
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006887 exocytosis GO:0007165 signal transduction GO:0032956 regulation of actin cytoskeleton organization GO:0035021 negative regulation of Rac protein signal transduction GO:0043087 regulation of GTPase activity GO:0043547 positive regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction GO:0061001 regulation of dendritic spine morphogenesis GO:0098886 modification of dendritic spine GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane
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