Human Gene ALDOC (ENST00000226253.9) from GENCODE V44
Description: Homo sapiens aldolase, fructose-bisphosphate C (ALDOC), mRNA. (from RefSeq NM_005165) RefSeq Summary (NM_005165): This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000226253.9 Gencode Gene: ENSG00000109107.14 Transcript (Including UTRs) Position: hg38 chr17:28,573,120-28,576,895 Size: 3,776 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr17:28,573,526-28,575,532 Size: 2,007 Coding Exon Count: 8
ID:ALDOC_HUMAN DESCRIPTION: RecName: Full=Fructose-bisphosphate aldolase C; EC=4.1.2.13; AltName: Full=Brain-type aldolase; CATALYTIC ACTIVITY: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=10.7 uM for fructose 1,6-bisphosphate; KM=16 mM for fructose 1-phosphate; PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 4/4. SUBUNIT: Homotetramer. Interacts with ATP6V1E1. May interact with PLD2. MISCELLANEOUS: In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain. SIMILARITY: Belongs to the class I fructose-bisphosphate aldolase family. SEQUENCE CAUTION: Sequence=AAI03761.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09972
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF209214 - JP 2014500723-A/16717: Polycomb-Associated Non-Coding RNAs. MA444791 - JP 2018138019-A/16717: Polycomb-Associated Non-Coding RNAs. AK294157 - Homo sapiens cDNA FLJ52210 complete cds, highly similar to Fructose-bisphosphate aldolase C (EC 4.1.2.13). AF054987 - Homo sapiens clone 23831 aldolase C mRNA, complete cds. BC003613 - Homo sapiens aldolase C, fructose-bisphosphate, mRNA (cDNA clone MGC:1449 IMAGE:2987869), complete cds. BC065565 - Homo sapiens aldolase C, fructose-bisphosphate, mRNA (cDNA clone MGC:75098 IMAGE:6155379), complete cds. BC103760 - Homo sapiens aldolase C, fructose-bisphosphate, mRNA (cDNA clone IMAGE:6139644), partial cds. AK293623 - Homo sapiens cDNA FLJ52578 complete cds, highly similar to Fructose-bisphosphate aldolase C (EC 4.1.2.13). AK293693 - Homo sapiens cDNA FLJ52222 complete cds, highly similar to Fructose-bisphosphate aldolase C (EC4.1.2.13). BC106925 - Homo sapiens aldolase C, fructose-bisphosphate, mRNA (cDNA clone MGC:126080 IMAGE:40032967), complete cds. BC106926 - Homo sapiens aldolase C, fructose-bisphosphate, mRNA (cDNA clone MGC:126081 IMAGE:40032968), complete cds. AK294091 - Homo sapiens cDNA FLJ51814 complete cds, highly similar to Fructose-bisphosphate aldolase C (EC 4.1.2.13). AK296039 - Homo sapiens cDNA FLJ50972 complete cds, highly similar to Fructose-bisphosphate aldolase C (EC 4.1.2.13). AK296053 - Homo sapiens cDNA FLJ56450 complete cds, highly similar to Fructose-bisphosphate aldolase C (EC 4.1.2.13). CR541862 - Homo sapiens full open reading frame cDNA clone RZPDo834F0832D for gene ALDOC, aldolase C, fructose-bisphosphate; complete cds, incl. stopcodon. GQ891338 - Homo sapiens clone HEL-S-109d epididymis secretory sperm binding protein mRNA, complete cds. AK312281 - Homo sapiens cDNA, FLJ92580, Homo sapiens aldolase C, fructose-bisphosphate (ALDOC), mRNA. BT007006 - Homo sapiens aldolase C, fructose-bisphosphate mRNA, complete cds. KJ890660 - Synthetic construct Homo sapiens clone ccsbBroadEn_00054 ALDOC gene, encodes complete protein. CR541881 - Homo sapiens full open reading frame cDNA clone RZPDo834A0533D for gene ALDOC, aldolase C, fructose-bisphosphate; complete cds, without stopcodon. JD228529 - Sequence 209553 from Patent EP1572962. JD271141 - Sequence 252165 from Patent EP1572962. JD293837 - Sequence 274861 from Patent EP1572962. JD521649 - Sequence 502673 from Patent EP1572962. JD164668 - Sequence 145692 from Patent EP1572962. JD393382 - Sequence 374406 from Patent EP1572962. JD153881 - Sequence 134905 from Patent EP1572962. JD117601 - Sequence 98625 from Patent EP1572962. JD480345 - Sequence 461369 from Patent EP1572962. JD355747 - Sequence 336771 from Patent EP1572962. JD145533 - Sequence 126557 from Patent EP1572962. JD421778 - Sequence 402802 from Patent EP1572962. JD259839 - Sequence 240863 from Patent EP1572962. JD403863 - Sequence 384887 from Patent EP1572962. JD548578 - Sequence 529602 from Patent EP1572962. JD380428 - Sequence 361452 from Patent EP1572962. JD381380 - Sequence 362404 from Patent EP1572962. JD060819 - Sequence 41843 from Patent EP1572962. LF326848 - JP 2014500723-A/134351: Polycomb-Associated Non-Coding RNAs. MA562425 - JP 2018138019-A/134351: Polycomb-Associated Non-Coding RNAs. AK293453 - Homo sapiens cDNA FLJ52121 complete cds, highly similar to Fructose-bisphosphate aldolase C (EC4.1.2.13). LF326847 - JP 2014500723-A/134350: Polycomb-Associated Non-Coding RNAs. MA562424 - JP 2018138019-A/134350: Polycomb-Associated Non-Coding RNAs. JD236566 - Sequence 217590 from Patent EP1572962. JD021380 - Sequence 2404 from Patent EP1572962. JD027743 - Sequence 8767 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00010 - Glycolysis / Gluconeogenesis hsa00030 - Pentose phosphate pathway hsa00051 - Fructose and mannose metabolism hsa01100 - Metabolic pathways
BioCyc Knowledge Library PWY66-373 - sucrose degradation PWY66-399 - gluconeogenesis PWY66-400 - glycolysis PWY66-407 - superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
Reactome (by CSHL, EBI, and GO)
Protein P09972 (Reactome details) participates in the following event(s):