Human Gene TAF15 (ENST00000605844.6) from GENCODE V44
Description: Homo sapiens TATA-box binding protein associated factor 15 (TAF15), transcript variant 1, mRNA. (from RefSeq NM_139215) RefSeq Summary (NM_139215): This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]. Gencode Transcript: ENST00000605844.6 Gencode Gene: ENSG00000270647.7 Transcript (Including UTRs) Position: hg38 chr17:35,809,484-35,847,242 Size: 37,759 Total Exon Count: 16 Strand: + Coding Region Position: hg38 chr17:35,809,570-35,846,945 Size: 37,376 Coding Exon Count: 16
ID:RBP56_HUMAN DESCRIPTION: RecName: Full=TATA-binding protein-associated factor 2N; AltName: Full=68 kDa TATA-binding protein-associated factor; Short=TAF(II)68; Short=TAFII68; AltName: Full=RNA-binding protein 56; FUNCTION: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). SUBUNIT: Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the TATA-binding protein (TBP) and other TBP-associated factors (TAF(II)s). Binds SF1. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles from the nucleus to the cytoplasm. TISSUE SPECIFICITY: Ubiquitous. Observed in all fetal and adult tissues. PTM: Dimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization and positive regulation of TAF15 transcriptional activity. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Note=A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3. SIMILARITY: Belongs to the RRM TET family. SIMILARITY: Contains 1 RanBP2-type zinc finger. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TAF2NID256.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/taf15/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PF00641 - Zn-finger in Ran binding protein and others
ModBase Predicted Comparative 3D Structure on Q92804
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006367 transcription initiation from RNA polymerase II promoter GO:0045893 positive regulation of transcription, DNA-templated GO:1901796 regulation of signal transduction by p53 class mediator
BC048985 - Homo sapiens TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa, mRNA (cDNA clone IMAGE:5266186). BC030591 - Homo sapiens TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa, mRNA (cDNA clone IMAGE:4829714). AK307637 - Homo sapiens cDNA, FLJ97585. AK314194 - Homo sapiens cDNA, FLJ94920, Homo sapiens TAF15 RNA polymerase II, TATA box binding protein(TBP)-associated factor, 68kDa (TAF15), transcript variant 1, mRNA. AK304520 - Homo sapiens cDNA FLJ53422 complete cds, highly similar to TATA-binding protein-associated factor 2N. U51334 - Human putative RNA binding protein (RBP56) mRNA, complete cds. AK313223 - Homo sapiens cDNA, FLJ93725, Homo sapiens TAF15 RNA polymerase II, TATA box binding protein(TBP)-associated factor, 68kDa (TAF15), transcript variant 2, mRNA. BC046099 - Homo sapiens TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa, mRNA (cDNA clone MGC:57515 IMAGE:6067044), complete cds. X98893 - H.sapiens mRNA for TBP associated factor, TAFII68. AB590937 - Synthetic construct DNA, clone: pFN21AE2015, Homo sapiens TAF15 gene for TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa, without stop codon, in Flexi system. KJ897810 - Synthetic construct Homo sapiens clone ccsbBroadEn_07204 TAF15 gene, encodes complete protein. AF162670 - Homo sapiens hTAFII68-CHN fusion protein mRNA, partial cds. AJ243810 - Homo sapiens partial mRNA for RBP56/CHN chimeric transcript. BC039129 - Homo sapiens TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa, mRNA (cDNA clone IMAGE:4148744). JD528887 - Sequence 509911 from Patent EP1572962. JD528867 - Sequence 509891 from Patent EP1572962. JD498328 - Sequence 479352 from Patent EP1572962. JD093868 - Sequence 74892 from Patent EP1572962. JD166508 - Sequence 147532 from Patent EP1572962. JD563670 - Sequence 544694 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q92804 (Reactome details) participates in the following event(s):
R-HSA-109636 Recognition and Binding of Core Promoter Elements by TFIID R-HSA-73946 Abortive initiation R-HSA-75856 Abortive Initiation Before Second Transition R-HSA-75873 Addition of Nucleotides 5 through 9 on the growing Transcript R-HSA-167136 Addition of nucleotides 5 through 9 on the growing HIV-1 transcript R-HSA-167474 Abortive HIV-1 Initiation Before Second Transition R-HSA-167477 Abortive HIV-1 initiation after formation of the first phosphodiester bond R-HSA-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP R-HSA-75861 NTP Binds Active Site of RNA Polymerase II R-HSA-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released R-HSA-109637 Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex R-HSA-75862 Fall Back to Closed Pre-initiation Complex R-HSA-75949 RNA Polymerase II Promoter Opening: First Transition R-HSA-167134 Newly formed phosphodiester bond stabilized and PPi released R-HSA-167130 Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP R-HSA-167118 NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex R-HSA-167484 Fall Back to Closed Pre-initiation Complex R-HSA-167097 HIV Promoter Opening: First Transition R-HSA-6805399 TAF1 phosphorylates TP53 R-HSA-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex R-HSA-75095 Binding of TFIIE to the growing preinitiation complex R-HSA-109639 Formation of the closed pre-initiation complex R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167161 HIV Transcription Initiation R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-167172 Transcription of the HIV genome R-HSA-73857 RNA Polymerase II Transcription R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-74160 Gene expression (Transcription) R-HSA-5633007 Regulation of TP53 Activity R-HSA-162587 HIV Life Cycle R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-162906 HIV Infection R-HSA-212436 Generic Transcription Pathway R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
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