ID:GGNB2_HUMAN DESCRIPTION: RecName: Full=Gametogenetin-binding protein 2; AltName: Full=Laryngeal carcinoma-related protein 1; AltName: Full=Protein ZNF403; FUNCTION: May be involved in spermatogenesis. SUBUNIT: Interacts with GGN (By similarity). SUBCELLULAR LOCATION: Cytoplasmic vesicle (By similarity). Note=Associated with vesicular structures (By similarity). TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed more abundantly in heart, pancreas and skeletal muscle. MISCELLANEOUS: Strongly down-regulated in 40% of primary laryngeal carcinoma and in 6 of 10 various cancer cell lines. SEQUENCE CAUTION: Sequence=BAB15031.1; Type=Frameshift; Positions=387; Sequence=BAB15397.1; Type=Erroneous initiation; Sequence=CAC18878.1; Type=Frameshift; Positions=433;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H3C7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0007275 multicellular organism development GO:0007283 spermatogenesis GO:0008285 negative regulation of cell proliferation GO:0010629 negative regulation of gene expression GO:0030154 cell differentiation GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein GO:0060711 labyrinthine layer development GO:0060716 labyrinthine layer blood vessel development GO:0061099 negative regulation of protein tyrosine kinase activity
AK292161 - Homo sapiens cDNA FLJ75305 complete cds, highly similar to Homo sapiens laryngeal carcinoma related protein 1 mRNA. AK024883 - Homo sapiens cDNA: FLJ21230 fis, clone COL00741. LP895340 - Sequence 204 from Patent EP3253886. AF268387 - Homo sapiens laryngeal carcinoma related protein 1 mRNA, complete cds. BC137491 - Homo sapiens gametogenetin binding protein 2, mRNA (cDNA clone MGC:169114 IMAGE:9021491), complete cds. AK290687 - Homo sapiens cDNA FLJ75663 complete cds, highly similar to Homo sapiens zinc finger protein 403 (ZNF403), mRNA. AF126964 - Homo sapiens C3HC4-type zinc finger protein (LZK1) mRNA, complete cds. AK301614 - Homo sapiens cDNA FLJ56588 complete cds, highly similar to Protein ZNF403. JD187698 - Sequence 168722 from Patent EP1572962. JD466334 - Sequence 447358 from Patent EP1572962. JD265045 - Sequence 246069 from Patent EP1572962. AK124053 - Homo sapiens cDNA FLJ42059 fis, clone SYNOV2005216, moderately similar to Homo sapiens laryngeal carcinoma related protein 1 mRNA. AK124084 - Homo sapiens cDNA FLJ42090 fis, clone TESOP2001605, highly similar to Protein ZNF403. DL492408 - Novel nucleic acids. DL490888 - Novel nucleic acids. AK026214 - Homo sapiens cDNA: FLJ22561 fis, clone HSI01788. AJ404670 - Homo sapiens mRNA for hypothetical protein, clone JuaW-XI-88. JD067200 - Sequence 48224 from Patent EP1572962.
US Server
