Human Gene LASP1 (ENST00000318008.11) from GENCODE V44
Description: Homo sapiens LIM and SH3 protein 1 (LASP1), transcript variant 1, mRNA. (from RefSeq NM_006148) RefSeq Summary (NM_006148): This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]. Gencode Transcript: ENST00000318008.11 Gencode Gene: ENSG00000002834.19 Transcript (Including UTRs) Position: hg38 chr17:38,870,058-38,921,770 Size: 51,713 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr17:38,870,190-38,918,778 Size: 48,589 Coding Exon Count: 7
ID:LASP1_HUMAN DESCRIPTION: RecName: Full=LIM and SH3 domain protein 1; Short=LASP-1; AltName: Full=Metastatic lymph node gene 50 protein; Short=MLN 50; FUNCTION: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). SUBUNIT: Interacts with F-actin (By similarity). Interacts with ANKRD54 (By similarity). INTERACTION: Q99750:MDFI; NbExp=3; IntAct=EBI-742828, EBI-724076; Q15645:TRIP13; NbExp=3; IntAct=EBI-742828, EBI-358993; SUBCELLULAR LOCATION: Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with the F-actin rich cortical cytoskeleton (By similarity). SIMILARITY: Contains 1 LIM zinc-binding domain. SIMILARITY: Contains 2 nebulin repeats. SIMILARITY: Contains 1 SH3 domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/Lasp1ID203.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14847
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.