Human Gene KRTAP1-5 (ENST00000361883.6) from GENCODE V44
Description: Homo sapiens keratin associated protein 1-5 (KRTAP1-5), mRNA. (from RefSeq NM_031957) RefSeq Summary (NM_031957): This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000361883.6 Gencode Gene: ENSG00000221852.5 Transcript (Including UTRs) Position: hg38 chr17:41,026,026-41,027,208 Size: 1,183 Total Exon Count: 1 Strand: - Coding Region Position: hg38 chr17:41,026,631-41,027,155 Size: 525 Coding Exon Count: 1
ID:KRA15_HUMAN DESCRIPTION: RecName: Full=Keratin-associated protein 1-5; AltName: Full=High sulfur keratin-associated protein 1.5; AltName: Full=Keratin-associated protein 1.5; FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. SUBUNIT: Interacts with hair keratins. TISSUE SPECIFICITY: Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone. SIMILARITY: Belongs to the KRTAP type 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01500 - Keratin, high sulfur B2 protein
ModBase Predicted Comparative 3D Structure on Q9BYS1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
US Server
