Human Gene DNAJC7 (ENST00000457167.9) from GENCODE V44
  Description: Homo sapiens DnaJ heat shock protein family (Hsp40) member C7 (DNAJC7), transcript variant 1, mRNA. (from RefSeq NM_003315)
RefSeq Summary (NM_003315): This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].
Gencode Transcript: ENST00000457167.9
Gencode Gene: ENSG00000168259.17
Transcript (Including UTRs)
   Position: hg38 chr17:41,976,435-42,017,439 Size: 41,005 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg38 chr17:41,976,733-42,017,416 Size: 40,684 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:41,976,435-42,017,439)mRNA (may differ from genome)Protein (494 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMalacardsMGIneXtProtOMIM
PubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DNJC7_HUMAN
DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 7; AltName: Full=Tetratricopeptide repeat protein 2; Short=TPR repeat protein 2;
FUNCTION: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone- substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).
SUBUNIT: Associates with complexes containing chaperones HSP70 and HSP90. Interacts with the GAP domain of NF1. Interacts with HSP90AA1. Interacts with HSPA1A/B; the interaction is enhanced by ATP. Interacts with HSP90AB1. Interacts with PGR. Interacts with RAD9A; the interaction is interrupted by UV and heat shock treatments. Interacts with HUS1 and RAD1. Interacts with NR1I3. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity). Interacts with HSPA8.
INTERACTION: P12504:vif (xeno); NbExp=3; IntAct=EBI-357552, EBI-779991;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Note=Colocalizes with NR1I3 to microtubules (By similarity).
SIMILARITY: Contains 1 J domain.
SIMILARITY: Contains 9 TPR repeats.
SEQUENCE CAUTION: Sequence=AAB36872.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH33772.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.77 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 1145.19 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.9023-0.083 Picture PostScript Text
3' UTR -81.10298-0.272 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001623 - DnaJ_N
IPR023114 - Elongated_TPR_rpt_dom
IPR003095 - Hsp_DnaJ
IPR001440 - TPR-1
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR019734 - TPR_repeat

Pfam Domains:
PF00226 - DnaJ domain
PF00515 - Tetratricopeptide repeat

ModBase Predicted Comparative 3D Structure on Q99615
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001671 ATPase activator activity
GO:0005515 protein binding
GO:0031072 heat shock protein binding

Biological Process:
GO:0006457 protein folding
GO:0032781 positive regulation of ATPase activity
GO:0051085 chaperone mediated protein folding requiring cofactor
GO:1900034 regulation of cellular response to heat

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LF384801 - JP 2014500723-A/192304: Polycomb-Associated Non-Coding RNAs.
MA620378 - JP 2018138019-A/192304: Polycomb-Associated Non-Coding RNAs.
BC003601 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 7, mRNA (cDNA clone MGC:911 IMAGE:3543074), complete cds.
BX647209 - Homo sapiens mRNA; cDNA DKFZp686I18256 (from clone DKFZp686I18256).
BC011837 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 7, mRNA (cDNA clone MGC:20075 IMAGE:3945721), complete cds.
AB209834 - Homo sapiens mRNA for DnaJ (Hsp40) homolog, subfamily C, member 7 variant protein.
U46571 - Human tetratricopeptide repeat protein (tpr2) mRNA, complete cds.
AK291047 - Homo sapiens cDNA FLJ76281 complete cds, highly similar to Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7), mRNA.
BC033772 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 7, mRNA (cDNA clone MGC:45296 IMAGE:3924081), complete cds.
AK298860 - Homo sapiens cDNA FLJ51941 complete cds, highly similar to DnaJ homolog subfamily C member 7.
JD472149 - Sequence 453173 from Patent EP1572962.
JD484125 - Sequence 465149 from Patent EP1572962.
JD077160 - Sequence 58184 from Patent EP1572962.
LF327796 - JP 2014500723-A/135299: Polycomb-Associated Non-Coding RNAs.
MA563373 - JP 2018138019-A/135299: Polycomb-Associated Non-Coding RNAs.
JD329473 - Sequence 310497 from Patent EP1572962.
AK296602 - Homo sapiens cDNA FLJ54791 complete cds, highly similar to DnaJ homolog subfamily C member 7.
JD429390 - Sequence 410414 from Patent EP1572962.
JD202697 - Sequence 183721 from Patent EP1572962.
AK316081 - Homo sapiens cDNA, FLJ78980 complete cds, highly similar to DnaJ homolog subfamily C member 7.
JD040791 - Sequence 21815 from Patent EP1572962.
LF327797 - JP 2014500723-A/135300: Polycomb-Associated Non-Coding RNAs.
MA563374 - JP 2018138019-A/135300: Polycomb-Associated Non-Coding RNAs.
KJ892328 - Synthetic construct Homo sapiens clone ccsbBroadEn_01722 DNAJC7 gene, encodes complete protein.
DQ893064 - Synthetic construct clone IMAGE:100005694; FLH193230.01X; RZPDo839E0178D DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7) gene, encodes complete protein.
KJ901813 - Synthetic construct Homo sapiens clone ccsbBroadEn_11207 DNAJC7 gene, encodes complete protein.
KJ892327 - Synthetic construct Homo sapiens clone ccsbBroadEn_01721 DNAJC7 gene, encodes complete protein.
DQ896317 - Synthetic construct Homo sapiens clone IMAGE:100010777; FLH193226.01L; RZPDo839E0168D DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7) gene, encodes complete protein.
AB587519 - Synthetic construct DNA, clone: pF1KE0031, Homo sapiens DNAJC7 gene for DnaJ (Hsp40) homolog, subfamily C, member 7, without stop codon, in Flexi system.
AM393511 - Synthetic construct Homo sapiens clone IMAGE:100002500 for hypothetical protein (DNAJC7 gene).
LF327799 - JP 2014500723-A/135302: Polycomb-Associated Non-Coding RNAs.
MA563376 - JP 2018138019-A/135302: Polycomb-Associated Non-Coding RNAs.
LF327800 - JP 2014500723-A/135303: Polycomb-Associated Non-Coding RNAs.
MA563377 - JP 2018138019-A/135303: Polycomb-Associated Non-Coding RNAs.
LF327801 - JP 2014500723-A/135304: Polycomb-Associated Non-Coding RNAs.
MA563378 - JP 2018138019-A/135304: Polycomb-Associated Non-Coding RNAs.
CU678526 - Synthetic construct Homo sapiens gateway clone IMAGE:100022474 5' read DNAJC7 mRNA.
LF327802 - JP 2014500723-A/135305: Polycomb-Associated Non-Coding RNAs.
MA563379 - JP 2018138019-A/135305: Polycomb-Associated Non-Coding RNAs.
AK308016 - Homo sapiens cDNA, FLJ97964.
LF327803 - JP 2014500723-A/135306: Polycomb-Associated Non-Coding RNAs.
MA563380 - JP 2018138019-A/135306: Polycomb-Associated Non-Coding RNAs.
LF327804 - JP 2014500723-A/135307: Polycomb-Associated Non-Coding RNAs.
MA563381 - JP 2018138019-A/135307: Polycomb-Associated Non-Coding RNAs.
CU680076 - Synthetic construct Homo sapiens gateway clone IMAGE:100019667 5' read DNAJC7 mRNA.
CU689734 - Synthetic construct Homo sapiens gateway clone IMAGE:100019617 5' read DNAJC7 mRNA.
JD022912 - Sequence 3936 from Patent EP1572962.
JD027821 - Sequence 8845 from Patent EP1572962.
LF327809 - JP 2014500723-A/135312: Polycomb-Associated Non-Coding RNAs.
MA563386 - JP 2018138019-A/135312: Polycomb-Associated Non-Coding RNAs.
LF327816 - JP 2014500723-A/135319: Polycomb-Associated Non-Coding RNAs.
MA563393 - JP 2018138019-A/135319: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q99615 (Reactome details) participates in the following event(s):

R-HSA-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol
R-HSA-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-3371556 Cellular response to heat stress
R-HSA-2262752 Cellular responses to stress
R-HSA-8953897 Cellular responses to external stimuli

-  Other Names for This Gene
  Alternate Gene Symbols: DNJC7_HUMAN, ENST00000457167.1, ENST00000457167.2, ENST00000457167.3, ENST00000457167.4, ENST00000457167.5, ENST00000457167.6, ENST00000457167.7, ENST00000457167.8, NM_003315, Q7Z784, Q99615, TPR2, TTC2, uc002hyo.1, uc002hyo.2, uc002hyo.3, uc002hyo.4, uc002hyo.5
UCSC ID: ENST00000457167.9
RefSeq Accession: NM_003315
Protein: Q99615 (aka DNJC7_HUMAN or DJC7_HUMAN)
CCDS: CCDS45677.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.