Human Gene TMEM106A (ENST00000612339.4) from GENCODE V44
  Description: Homo sapiens transmembrane protein 106A (TMEM106A), transcript variant 2, mRNA. (from RefSeq NM_145041)
Gencode Transcript: ENST00000612339.4
Gencode Gene: ENSG00000184988.8
Transcript (Including UTRs)
   Position: hg38 chr17:43,211,875-43,220,041 Size: 8,167 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr17:43,213,042-43,217,801 Size: 4,760 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:43,211,875-43,220,041)mRNA (may differ from genome)Protein (262 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: T106A_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 106A;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM106 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -71.70237-0.303 Picture PostScript Text
3' UTR -830.302240-0.371 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009790 - DUF1356_TMEM106

Pfam Domains:
PF07092 - Protein of unknown function (DUF1356)

ModBase Predicted Comparative 3D Structure on Q96A25
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF209358 - JP 2014500723-A/16861: Polycomb-Associated Non-Coding RNAs.
MA444935 - JP 2018138019-A/16861: Polycomb-Associated Non-Coding RNAs.
AK290387 - Homo sapiens cDNA FLJ77644 complete cds.
AK299974 - Homo sapiens cDNA FLJ50420 complete cds, highly similar to Transmembrane protein 106A.
AK301571 - Homo sapiens cDNA FLJ50717 complete cds, highly similar to Transmembrane protein 106A.
AK056132 - Homo sapiens cDNA FLJ31570 fis, clone NT2RI2001657.
JD143233 - Sequence 124257 from Patent EP1572962.
BC012139 - Homo sapiens transmembrane protein 106A, mRNA (cDNA clone MGC:20235 IMAGE:4562851), complete cds.
JD210212 - Sequence 191236 from Patent EP1572962.
BC147023 - Homo sapiens similar to transmembrane protein 106A, mRNA (cDNA clone MGC:182126 IMAGE:9056951), complete cds.
BC146974 - Homo sapiens similar to transmembrane protein 106A, mRNA (cDNA clone MGC:182077 IMAGE:9056902), complete cds.
BC146976 - Homo sapiens transmembrane protein 106A, mRNA (cDNA clone MGC:182079 IMAGE:9056904), complete cds.
BC157892 - Homo sapiens transmembrane protein 106A, mRNA (cDNA clone MGC:189773 IMAGE:9057097), complete cds.
JD290055 - Sequence 271079 from Patent EP1572962.
JD042905 - Sequence 23929 from Patent EP1572962.
CU680236 - Synthetic construct Homo sapiens gateway clone IMAGE:100016920 5' read TMEM106A mRNA.
HQ447171 - Synthetic construct Homo sapiens clone IMAGE:100070459; CCSB007230_01 transmembrane protein 106A (TMEM106A) gene, encodes complete protein.
KJ895252 - Synthetic construct Homo sapiens clone ccsbBroadEn_04646 TMEM106A gene, encodes complete protein.
U25750 - Human chromosome 17q21 mRNA clone 1046:1-1.
JD115638 - Sequence 96662 from Patent EP1572962.
JD195031 - Sequence 176055 from Patent EP1572962.
JD161972 - Sequence 142996 from Patent EP1572962.
JD427157 - Sequence 408181 from Patent EP1572962.
JD265093 - Sequence 246117 from Patent EP1572962.
JD148032 - Sequence 129056 from Patent EP1572962.
JD051084 - Sequence 32108 from Patent EP1572962.
JD425911 - Sequence 406935 from Patent EP1572962.
JD379457 - Sequence 360481 from Patent EP1572962.
JD309582 - Sequence 290606 from Patent EP1572962.
JD091451 - Sequence 72475 from Patent EP1572962.
JD317160 - Sequence 298184 from Patent EP1572962.
JD369613 - Sequence 350637 from Patent EP1572962.
JD495950 - Sequence 476974 from Patent EP1572962.
JD452102 - Sequence 433126 from Patent EP1572962.
JD160400 - Sequence 141424 from Patent EP1572962.
JD421017 - Sequence 402041 from Patent EP1572962.
JD208484 - Sequence 189508 from Patent EP1572962.
JD513702 - Sequence 494726 from Patent EP1572962.
JD303660 - Sequence 284684 from Patent EP1572962.
JD278245 - Sequence 259269 from Patent EP1572962.
JD404890 - Sequence 385914 from Patent EP1572962.
JD454131 - Sequence 435155 from Patent EP1572962.
JD543948 - Sequence 524972 from Patent EP1572962.
JD543949 - Sequence 524973 from Patent EP1572962.
JD543953 - Sequence 524977 from Patent EP1572962.
JD224840 - Sequence 205864 from Patent EP1572962.
JD185860 - Sequence 166884 from Patent EP1572962.
JD185861 - Sequence 166885 from Patent EP1572962.
JD481341 - Sequence 462365 from Patent EP1572962.
JD481340 - Sequence 462364 from Patent EP1572962.
JD291677 - Sequence 272701 from Patent EP1572962.
JD340926 - Sequence 321950 from Patent EP1572962.
JD144580 - Sequence 125604 from Patent EP1572962.
JD144581 - Sequence 125605 from Patent EP1572962.
JD112274 - Sequence 93298 from Patent EP1572962.
JD497139 - Sequence 478163 from Patent EP1572962.
JD497140 - Sequence 478164 from Patent EP1572962.
JD486645 - Sequence 467669 from Patent EP1572962.
JD275493 - Sequence 256517 from Patent EP1572962.
JD275494 - Sequence 256518 from Patent EP1572962.
JD275495 - Sequence 256519 from Patent EP1572962.
JD325407 - Sequence 306431 from Patent EP1572962.
JD257003 - Sequence 238027 from Patent EP1572962.
JD199438 - Sequence 180462 from Patent EP1572962.
JD453957 - Sequence 434981 from Patent EP1572962.
JD177497 - Sequence 158521 from Patent EP1572962.
JD177498 - Sequence 158522 from Patent EP1572962.
JD308931 - Sequence 289955 from Patent EP1572962.
JD332408 - Sequence 313432 from Patent EP1572962.
JD143909 - Sequence 124933 from Patent EP1572962.
JD229312 - Sequence 210336 from Patent EP1572962.
JD206647 - Sequence 187671 from Patent EP1572962.
JD228926 - Sequence 209950 from Patent EP1572962.
JD161486 - Sequence 142510 from Patent EP1572962.
JD161327 - Sequence 142351 from Patent EP1572962.
JD393572 - Sequence 374596 from Patent EP1572962.
JD349046 - Sequence 330070 from Patent EP1572962.
JD304595 - Sequence 285619 from Patent EP1572962.
JD046680 - Sequence 27704 from Patent EP1572962.
JD065650 - Sequence 46674 from Patent EP1572962.
JD442501 - Sequence 423525 from Patent EP1572962.
JD217104 - Sequence 198128 from Patent EP1572962.
JD301636 - Sequence 282660 from Patent EP1572962.
JD146809 - Sequence 127833 from Patent EP1572962.
JD564178 - Sequence 545202 from Patent EP1572962.
JD496615 - Sequence 477639 from Patent EP1572962.
JD052277 - Sequence 33301 from Patent EP1572962.
JD215437 - Sequence 196461 from Patent EP1572962.
JD487967 - Sequence 468991 from Patent EP1572962.
JD258648 - Sequence 239672 from Patent EP1572962.
JD046725 - Sequence 27749 from Patent EP1572962.
JD494339 - Sequence 475363 from Patent EP1572962.
JD426579 - Sequence 407603 from Patent EP1572962.
JD544956 - Sequence 525980 from Patent EP1572962.
JD229765 - Sequence 210789 from Patent EP1572962.
JD376222 - Sequence 357246 from Patent EP1572962.
JD324394 - Sequence 305418 from Patent EP1572962.
JD468900 - Sequence 449924 from Patent EP1572962.
JD437114 - Sequence 418138 from Patent EP1572962.
JD495787 - Sequence 476811 from Patent EP1572962.
JD258663 - Sequence 239687 from Patent EP1572962.
JD068193 - Sequence 49217 from Patent EP1572962.
JD074549 - Sequence 55573 from Patent EP1572962.
JD089056 - Sequence 70080 from Patent EP1572962.
JD135687 - Sequence 116711 from Patent EP1572962.
JD135688 - Sequence 116712 from Patent EP1572962.
JD238030 - Sequence 219054 from Patent EP1572962.
JD238031 - Sequence 219055 from Patent EP1572962.
LF327982 - JP 2014500723-A/135485: Polycomb-Associated Non-Coding RNAs.
MA563559 - JP 2018138019-A/135485: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K2X2, ENST00000612339.1, ENST00000612339.2, ENST00000612339.3, NM_145041, Q96A25, T106A_HUMAN, uc002idn.1, uc002idn.2
UCSC ID: ENST00000612339.4
RefSeq Accession: NM_145041
Protein: Q96A25 (aka T106A_HUMAN)
CCDS: CCDS11462.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.