Human Gene ITGB3 (uc002ili.1) Description and Page Index
Description: Homo sapiens integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ITGB3), mRNA. RefSeq Summary (NM_000212): The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M35999.1, M20311.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr17:45,331,208-45,368,565 Size: 37,358 Total Exon Count: 9 Strand: + Coding Region Position: hg19 chr17:45,331,228-45,368,526 Size: 37,299 Coding Exon Count: 9
ID:I3L4X8_HUMAN DESCRIPTION: RecName: Full=Integrin beta; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity). SIMILARITY: Belongs to the integrin beta chain family. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Genetic Association Studies of Complex Diseases and Disorders
aspirin resistance Macchi, L. et al. 2003, Resistance in vitro to low-dose aspirin is associated with platelet PlA1 (GP IIIa) polymorphism but not with C807T(GP Ia/IIa) and C-5T Kozak (GP Ibalpha) polymorphisms., Journal of the American College of Cardiology. 2003 Sep;42(6):1115-9.
Platelets homozygous for the Pl(A1) allele appear to be less sensitive to inhibitory action of low-dose aspirin. This differential sensitivity to aspirin may have potential clinical implications whereby specific antiplatelet therapy may be best tailored according to the patient's Pl(A) genotype.
asthma IgE wheezing Thompson, E. E. et al. 2007, Integrin beta3 genotype influences asthma and allergy phenotypes in the first 6 years of life, J Allergy Clin Immunol 2007 119(6) 1423-9.
Our results suggest that genetic variation in ITGB3 contributes to asthma susceptibility and allergic sensitization, and that the effects of this gene begin early in life.
asthma; allergy Weiss, L. A. et al. 2005, Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations., American journal of respiratory and critical care medicine. 2005 Jul;172(1):67-73.
This study provides evidence that ITGB3 plays a role in the pathogenesis of asthma and sensitization to mold allergens.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on I3L4X8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.