Human Gene NFE2L1 (ENST00000362042.8) from GENCODE V44
Description: Homo sapiens nuclear factor, erythroid 2 like 1 (NFE2L1), transcript variant 1, mRNA. (from RefSeq NM_003204) RefSeq Summary (NM_003204): This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for 'nuclear respiratory factor 1' which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000362042.8 Gencode Gene: ENSG00000082641.16 Transcript (Including UTRs) Position: hg38 chr17:48,048,359-48,061,545 Size: 13,187 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr17:48,051,119-48,059,641 Size: 8,523 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14494
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000976 transcription regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003712 transcription cofactor activity GO:0005515 protein binding GO:0008289 lipid binding GO:0015485 cholesterol binding GO:0019904 protein domain specific binding GO:0044877 macromolecular complex binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006629 lipid metabolic process GO:0006783 heme biosynthetic process GO:0006954 inflammatory response GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0009653 anatomical structure morphogenesis GO:0030218 erythrocyte differentiation GO:0034599 cellular response to oxidative stress GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0042632 cholesterol homeostasis GO:0045454 cell redox homeostasis GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0055088 lipid homeostasis GO:0071397 cellular response to cholesterol GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress GO:1901329 regulation of odontoblast differentiation
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