Human Gene CBX1 (uc002ind.4) Description and Page Index
Description: Homo sapiens chromobox homolog 1 (CBX1), transcript variant 1, mRNA. RefSeq Summary (NM_006807): This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr17:46,147,414-46,178,560 Size: 31,147 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr17:46,148,797-46,154,366 Size: 5,570 Coding Exon Count: 4
ID:CBX1_HUMAN DESCRIPTION: RecName: Full=Chromobox protein homolog 1; AltName: Full=HP1Hsbeta; AltName: Full=Heterochromatin protein 1 homolog beta; Short=HP1 beta; AltName: Full=Heterochromatin protein p25; AltName: Full=M31; AltName: Full=Modifier 1 protein; AltName: Full=p25beta; FUNCTION: Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. SUBUNIT: Homodimer. Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain. Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain. Interacts with SUV39H1 and SETDB1, SUV420H1 and SUV420H2. Interacts with PRDM6. Interacts with POGZ. Interacts with CHAMP1. Interacts with ASXL1. INTERACTION: Q9H2P0:ADNP; NbExp=2; IntAct=EBI-78129, EBI-1764854; Q6IQ32:ADNP2; NbExp=2; IntAct=EBI-78129, EBI-2838654; P10588:NR2F6; NbExp=2; IntAct=EBI-78129, EBI-2681496; SUBCELLULAR LOCATION: Nucleus. Note=Unassociated with chromosomes during mitosis. TISSUE SPECIFICITY: Expressed in all adult and embryonic tissues. PTM: Not phosphorylated. PTM: Ubiquitinated. SIMILARITY: Contains 2 chromo domains. WEB RESOURCE: Name=Wikipedia; Note=Heterochromatin protein 1 entry; URL="http://en.wikipedia.org/wiki/Heterochromatin_Protein_1";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P83916
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.