Human Gene HOXB7 (uc002inv.3) Description and Page Index
Description: Homo sapiens homeobox B7 (HOXB7), mRNA. RefSeq Summary (NM_004502): This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M16937.1, SRR5189655.10159.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000239165.9/ ENSP00000239165.7 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr17:46,684,595-46,688,383 Size: 3,789 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr17:46,685,204-46,688,280 Size: 3,077 Coding Exon Count: 2
ID:HXB7_HUMAN DESCRIPTION: RecName: Full=Homeobox protein Hox-B7; AltName: Full=Homeobox protein HHO.C1; AltName: Full=Homeobox protein Hox-2C; FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. INTERACTION: P78527:PRKDC; NbExp=2; IntAct=EBI-1248457, EBI-352053; P13010:XRCC5; NbExp=9; IntAct=EBI-1248457, EBI-357997; SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the Antp homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): HOXB7 CDC HuGE Published Literature: HOXB7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09629
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0009952 anterior/posterior pattern specification GO:0030099 myeloid cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048704 embryonic skeletal system morphogenesis GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis