Human Gene ABI3 (uc002iop.1) Description and Page Index
Description: Homo sapiens ABI family, member 3 (ABI3), transcript variant 1, mRNA. RefSeq Summary (NM_016428): This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]. Transcript (Including UTRs) Position: hg19 chr17:47,287,589-47,300,587 Size: 12,999 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr17:47,288,087-47,300,077 Size: 11,991 Coding Exon Count: 8
ID:ABI3_HUMAN DESCRIPTION: RecName: Full=ABI gene family member 3; AltName: Full=New molecule including SH3; Short=Nesh; FUNCTION: May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility. SUBUNIT: May interact with PAK1 and PAK2. Probably interacts with TARSH. INTERACTION: O15372:EIF3H; NbExp=3; IntAct=EBI-742038, EBI-709735; SUBCELLULAR LOCATION: Cytoplasm. Note=Colocalizes with PAK2 at leading edge of cells. TISSUE SPECIFICITY: Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle. SIMILARITY: Belongs to the ABI family. SIMILARITY: Contains 1 SH3 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P2A4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.