Human Gene PHOSPHO1 (uc002ios.2) Description and Page Index
  Description: Homo sapiens phosphatase, orphan 1 (PHOSPHO1), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:47,300,732-47,308,128 Size: 7,397 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr17:47,301,608-47,302,486 Size: 879 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:47,300,732-47,308,128)mRNA (may differ from genome)Protein (292 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: E9PAM0_HUMAN
DESCRIPTION: SubName: Full=Phosphoethanolamine/phosphocholine phosphatase;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PHOSPHO1
CDC HuGE Published Literature: PHOSPHO1

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 79.57 RPKM in Whole Blood
Total median expression: 186.50 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -173.70418-0.416 Picture PostScript Text
3' UTR -348.82876-0.398 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023214 - HAD-like_dom
IPR006383 - HAD-SF_hydro_IB_PSP-like
IPR016965 - Pase_PHOSPHO-typ
IPR006384 - PyrdxlP_Pase-rel

Pfam Domains:
PF06888 - Putative Phosphatase
PF12710 - haloacid dehalogenase-like hydrolase

SCOP Domains:
56784 - HAD-like

ModBase Predicted Comparative 3D Structure on E9PAM0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AJ457189 - Homo sapiens partial mRNA for phosphatase, orphan 1 (phospho1 gene).
JD335044 - Sequence 316068 from Patent EP1572962.
JD232672 - Sequence 213696 from Patent EP1572962.
JD522831 - Sequence 503855 from Patent EP1572962.
JD470037 - Sequence 451061 from Patent EP1572962.
JD054558 - Sequence 35582 from Patent EP1572962.
JD366909 - Sequence 347933 from Patent EP1572962.
BC117187 - Homo sapiens phosphatase, orphan 1, mRNA (cDNA clone MGC:150796 IMAGE:40125738), complete cds.
BC143884 - Homo sapiens cDNA clone IMAGE:9052400.
JD324070 - Sequence 305094 from Patent EP1572962.
JD506410 - Sequence 487434 from Patent EP1572962.
JD479891 - Sequence 460915 from Patent EP1572962.
JD128802 - Sequence 109826 from Patent EP1572962.
JD460191 - Sequence 441215 from Patent EP1572962.
JD099595 - Sequence 80619 from Patent EP1572962.
JD048186 - Sequence 29210 from Patent EP1572962.
JD214824 - Sequence 195848 from Patent EP1572962.
JD226695 - Sequence 207719 from Patent EP1572962.
JD184786 - Sequence 165810 from Patent EP1572962.
JD380303 - Sequence 361327 from Patent EP1572962.
KJ895724 - Synthetic construct Homo sapiens clone ccsbBroadEn_05118 PHOSPHO1 gene, encodes complete protein.
DQ570692 - Homo sapiens piRNA piR-30804, complete sequence.
BC029931 - Homo sapiens phosphatase, orphan 1, mRNA (cDNA clone IMAGE:5165504), with apparent retained intron.
JD197257 - Sequence 178281 from Patent EP1572962.
JD540940 - Sequence 521964 from Patent EP1572962.
JD484352 - Sequence 465376 from Patent EP1572962.
JD484248 - Sequence 465272 from Patent EP1572962.
JD484351 - Sequence 465375 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00564 - Glycerophospholipid metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: E9PAM0, E9PAM0_HUMAN, NM_001143804, NP_001137276
UCSC ID: uc002ios.2
RefSeq Accession: NM_001143804
Protein: E9PAM0 CCDS: CCDS45726.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001143804.1
exon count: 3CDS single in 3' UTR: no RNA size: 2173
ORF size: 879CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1723.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.