Human Gene ZNF652 (uc002iow.3) Description and Page Index
  Description: Homo sapiens zinc finger protein 652 (ZNF652), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:47,366,568-47,439,835 Size: 73,268 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr17:47,375,775-47,395,087 Size: 19,313 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:47,366,568-47,439,835)mRNA (may differ from genome)Protein (606 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 652;
FUNCTION: Functions as a transcriptional repressor.
SUBUNIT: Interacts with CBFA2T3.
INTERACTION: O75081:CBFA2T3; NbExp=2; IntAct=EBI-1190229, EBI-1190217;
TISSUE SPECIFICITY: Widely expressed with higher expression in breast, prostate, vulva and pancreas.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 9 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=BAA76768.2; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF652
CDC HuGE Published Literature: ZNF652
Positive Disease Associations: Alcoholism , Blood Pressure , Diastolic blood pressure , Prostatic Neoplasms
Related Studies:
  1. Alcoholism
    , , . [PubMed 0]
  2. Blood Pressure
    Christopher Newton-Cheh et al. Nature genetics 2009, Genome-wide association study identifies eight loci associated with blood pressure., Nature genetics. [PubMed 19430483]
  3. Blood Pressure
    Louise V Wain et al. Nature genetics 2011, Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure., Nature genetics. [PubMed 21909110]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.35 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 238.00 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -80.50319-0.252 Picture PostScript Text
3' UTR -2601.399207-0.283 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9Y2D9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  BC034987 - Homo sapiens zinc finger protein 652, mRNA (cDNA clone IMAGE:5267026), with apparent retained intron.
BC028045 - Homo sapiens, clone IMAGE:4148741, mRNA.
AK093834 - Homo sapiens cDNA FLJ36515 fis, clone TRACH2001810.
DQ591598 - Homo sapiens piRNA piR-58710, complete sequence.
DQ589455 - Homo sapiens piRNA piR-56567, complete sequence.
DQ578309 - Homo sapiens piRNA piR-46421, complete sequence.
BC152440 - Homo sapiens zinc finger protein 652, mRNA (cDNA clone MGC:176684 IMAGE:8862563), complete cds.
AB023141 - Homo sapiens KIAA0924 mRNA for KIAA0924 protein.
JD461359 - Sequence 442383 from Patent EP1572962.
JD151763 - Sequence 132787 from Patent EP1572962.
JD405297 - Sequence 386321 from Patent EP1572962.
JD522915 - Sequence 503939 from Patent EP1572962.
JD478123 - Sequence 459147 from Patent EP1572962.
JD537910 - Sequence 518934 from Patent EP1572962.
JD526126 - Sequence 507150 from Patent EP1572962.
JD541981 - Sequence 523005 from Patent EP1572962.
JD558983 - Sequence 540007 from Patent EP1572962.
JD352859 - Sequence 333883 from Patent EP1572962.
JD355621 - Sequence 336645 from Patent EP1572962.
JD092346 - Sequence 73370 from Patent EP1572962.
JD022334 - Sequence 3358 from Patent EP1572962.
JD183982 - Sequence 165006 from Patent EP1572962.
JD036116 - Sequence 17140 from Patent EP1572962.
JD066687 - Sequence 47711 from Patent EP1572962.
JD176486 - Sequence 157510 from Patent EP1572962.
JD138442 - Sequence 119466 from Patent EP1572962.
JD287118 - Sequence 268142 from Patent EP1572962.
JD349081 - Sequence 330105 from Patent EP1572962.
JD495869 - Sequence 476893 from Patent EP1572962.
JD107500 - Sequence 88524 from Patent EP1572962.
JD505731 - Sequence 486755 from Patent EP1572962.
JD070317 - Sequence 51341 from Patent EP1572962.
JD514141 - Sequence 495165 from Patent EP1572962.
JD514142 - Sequence 495166 from Patent EP1572962.
JD566091 - Sequence 547115 from Patent EP1572962.
JD370060 - Sequence 351084 from Patent EP1572962.
JD285501 - Sequence 266525 from Patent EP1572962.
JD071706 - Sequence 52730 from Patent EP1572962.
JD095128 - Sequence 76152 from Patent EP1572962.
JD059563 - Sequence 40587 from Patent EP1572962.
JD212928 - Sequence 193952 from Patent EP1572962.
JD428449 - Sequence 409473 from Patent EP1572962.
JD528179 - Sequence 509203 from Patent EP1572962.
JD291312 - Sequence 272336 from Patent EP1572962.
JD500966 - Sequence 481990 from Patent EP1572962.
JD550048 - Sequence 531072 from Patent EP1572962.
JD153694 - Sequence 134718 from Patent EP1572962.
JD228855 - Sequence 209879 from Patent EP1572962.
JD259788 - Sequence 240812 from Patent EP1572962.
JD528178 - Sequence 509202 from Patent EP1572962.
JD548277 - Sequence 529301 from Patent EP1572962.
JD291311 - Sequence 272335 from Patent EP1572962.
JD500965 - Sequence 481989 from Patent EP1572962.
JD550047 - Sequence 531071 from Patent EP1572962.
JD562022 - Sequence 543046 from Patent EP1572962.
JD550419 - Sequence 531443 from Patent EP1572962.
JD428445 - Sequence 409469 from Patent EP1572962.
CR933680 - Homo sapiens mRNA; cDNA DKFZp781E2122 (from clone DKFZp781E2122).
JD112044 - Sequence 93068 from Patent EP1572962.
JD416563 - Sequence 397587 from Patent EP1572962.
JD296110 - Sequence 277134 from Patent EP1572962.
JD234968 - Sequence 215992 from Patent EP1572962.
JD506196 - Sequence 487220 from Patent EP1572962.
JD072036 - Sequence 53060 from Patent EP1572962.
JD294798 - Sequence 275822 from Patent EP1572962.
JD489024 - Sequence 470048 from Patent EP1572962.
JD460026 - Sequence 441050 from Patent EP1572962.
JD067497 - Sequence 48521 from Patent EP1572962.
JD285910 - Sequence 266934 from Patent EP1572962.
JD554622 - Sequence 535646 from Patent EP1572962.
JD073464 - Sequence 54488 from Patent EP1572962.
JD095050 - Sequence 76074 from Patent EP1572962.
JD110067 - Sequence 91091 from Patent EP1572962.
JD304990 - Sequence 286014 from Patent EP1572962.
JD559368 - Sequence 540392 from Patent EP1572962.
JD184444 - Sequence 165468 from Patent EP1572962.
JD065904 - Sequence 46928 from Patent EP1572962.
JD302914 - Sequence 283938 from Patent EP1572962.
JD349634 - Sequence 330658 from Patent EP1572962.
AK292667 - Homo sapiens cDNA FLJ75819 complete cds, highly similar to Homo sapiens zinc finger protein 652 (ZNF652), mRNA.
JD226081 - Sequence 207105 from Patent EP1572962.
JD516871 - Sequence 497895 from Patent EP1572962.
JD445881 - Sequence 426905 from Patent EP1572962.
JD085400 - Sequence 66424 from Patent EP1572962.
JD248159 - Sequence 229183 from Patent EP1572962.
BC139779 - Homo sapiens zinc finger protein 652, mRNA (cDNA clone MGC:150547 IMAGE:40122232), complete cds.
AB384046 - Synthetic construct DNA, clone: pF1KSDA0924, Homo sapiens ZNF652 gene for zinc finger protein 652, complete cds, without stop codon, in Flexi system.
JD563907 - Sequence 544931 from Patent EP1572962.
JD091641 - Sequence 72665 from Patent EP1572962.
JD063468 - Sequence 44492 from Patent EP1572962.
JD185018 - Sequence 166042 from Patent EP1572962.
JD231141 - Sequence 212165 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A4QPD9, KIAA0924, NM_014897, NP_055712, Q5H9Q0, Q9Y2D9, ZN652_HUMAN
UCSC ID: uc002iow.3
RefSeq Accession: NM_014897
Protein: Q9Y2D9 (aka ZN652_HUMAN)
CCDS: CCDS32677.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_014897.2
exon count: 6CDS single in 3' UTR: no RNA size: 11347
ORF size: 1821CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3557.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 8900# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.