Human Gene NME2 (ENST00000514264.6) from GENCODE V44
Description: Homo sapiens NME/NM23 nucleoside diphosphate kinase 2 (NME2), transcript variant 2, mRNA. (from RefSeq NM_001018137) RefSeq Summary (NM_001018137): Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]. Gencode Transcript: ENST00000514264.6 Gencode Gene: ENSG00000243678.12 Transcript (Including UTRs) Position: hg38 chr17:51,165,435-51,171,744 Size: 6,310 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr17:51,166,831-51,171,604 Size: 4,774 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6FHN3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
