Human Gene FDXR (ENST00000581530.5) from GENCODE V44
Description: Homo sapiens ferredoxin reductase (FDXR), transcript variant 2, mRNA. (from RefSeq NM_004110)
RefSeq Summary (NM_004110): This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012].
Gencode Transcript: ENST00000581530.5
Gencode Gene: ENSG00000161513.12
Transcript (Including UTRs)
Position: hg38 chr17:74,862,501-74,872,961 Size: 10,461 Total Exon Count: 12 Strand: -
Coding Region
Position: hg38 chr17:74,862,817-74,872,944 Size: 10,128 Coding Exon Count: 12
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D013749
Tetrachlorodibenzodioxin
D000082
Acetaminophen
D001564
Benzo(a)pyrene
D003993
Dibutyl Phthalate
D004997
Ethinyl Estradiol
C517041
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
D015655
1-Methyl-4-phenylpyridinium
C111118
2',3,3',4',5-pentachloro-4-hydroxybiphenyl
C404910
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane
C016403
2,4-dinitrotoluene
more ... click here to view the complete list
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
LF209416 - JP 2014500723-A/16919: Polycomb-Associated Non-Coding RNAs.MA444993 - JP 2018138019-A/16919: Polycomb-Associated Non-Coding RNAs.BC002960 - Homo sapiens ferredoxin reductase, mRNA (cDNA clone MGC:1505 IMAGE:3537008), complete cds.GQ891439 - Homo sapiens clone HEL-S-160 epididymis secretory sperm binding protein mRNA, complete cds.BC018911 - Homo sapiens ferredoxin reductase, mRNA (cDNA clone IMAGE:4080044).BC011521 - Homo sapiens ferredoxin reductase, mRNA (cDNA clone IMAGE:4155893), with apparent retained intron.AK301977 - Homo sapiens cDNA FLJ54567 complete cds, highly similar to NADPH:adrenodoxin oxidoreductase, mitochondrial precursor (EC 1.18.1.2).AK098648 - Homo sapiens cDNA FLJ25782 fis, clone TST06643, highly similar to NADPH:ADRENODOXIN OXIDOREDUCTASE PRECURSOR (EC 1.18.1.2).AK298908 - Homo sapiens cDNA FLJ59386 complete cds, highly similar to NADPH:adrenodoxin oxidoreductase, mitochondrial precursor (EC 1.18.1.2).BC063493 - Homo sapiens ferredoxin reductase, mRNA (cDNA clone MGC:70675 IMAGE:5404814), complete cds.BC034763 - Homo sapiens, Similar to ferredoxin reductase, clone IMAGE:5197984, mRNA.AK094120 - Homo sapiens cDNA FLJ36801 fis, clone ADRGL2007810, highly similar to NADPH:adrenodoxin oxidoreductase, mitochondrial precursor (EC 1.18.1.2).JD561159 - Sequence 542183 from Patent EP1572962.JD561160 - Sequence 542184 from Patent EP1572962.J03826 - Homo sapiens adrenodoxin reductase precursor species (FDXR) mRNA, alternatively spliced, complete cds.AK293210 - Homo sapiens cDNA FLJ59458 complete cds, highly similar to NADPH:adrenodoxin oxidoreductase, mitochondrial precursor (EC 1.18.1.2).AK301779 - Homo sapiens cDNA FLJ54040 complete cds, highly similar to NADPH:adrenodoxin oxidoreductase, mitochondrial precursor (EC 1.18.1.2).JD386231 - Sequence 367255 from Patent EP1572962.AK295307 - Homo sapiens cDNA FLJ53329 complete cds, highly similar to NADPH:adrenodoxin oxidoreductase, mitochondrial precursor (EC 1.18.1.2).AK293208 - Homo sapiens cDNA FLJ59457 complete cds, highly similar to NADPH:adrenodoxin oxidoreductase, mitochondrial precursor (EC 1.18.1.2).AK223530 - Homo sapiens mRNA for ferredoxin reductase isoform 1 precursor variant, clone: FCC124G01.JD387458 - Sequence 368482 from Patent EP1572962.JD387412 - Sequence 368436 from Patent EP1572962.JD537983 - Sequence 519007 from Patent EP1572962.KJ891156 - Synthetic construct Homo sapiens clone ccsbBroadEn_00550 FDXR gene, encodes complete protein.BT006684 - Homo sapiens ferredoxin reductase mRNA, complete cds.AB463633 - Synthetic construct DNA, clone: pF1KB8117, Homo sapiens FDXR gene for ferredoxin reductase, without stop codon, in Flexi system.LF328368 - JP 2014500723-A/135871: Polycomb-Associated Non-Coding RNAs.MA563945 - JP 2018138019-A/135871: Polycomb-Associated Non-Coding RNAs.CU678312 - Synthetic construct Homo sapiens gateway clone IMAGE:100018346 5' read FDXR mRNA.
Other Names for This Gene
Alternate Gene Symbols: A0A0C4DGN7, ENST00000581530.1, ENST00000581530.2, ENST00000581530.3, ENST00000581530.4, NM_004110, uc002jlx.1, uc002jlx.2, uc002jlx.3, uc002jlx.4UCSC ID: ENST00000581530.5RefSeq Accession: NM_004110
CCDS: CCDS11707.1 , CCDS58592.1 , CCDS58593.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.