Human Gene MRPS7 (ENST00000245539.11) from GENCODE V44
Description: Homo sapiens mitochondrial ribosomal protein S7 (MRPS7), mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_015971) RefSeq Summary (NM_015971): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16 S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000245539.11 Gencode Gene: ENSG00000125445.11 Transcript (Including UTRs) Position: hg38 chr17:75,261,879-75,266,376 Size: 4,498 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr17:75,261,901-75,265,923 Size: 4,023 Coding Exon Count: 5
ID:RT07_HUMAN DESCRIPTION: RecName: Full=28S ribosomal protein S7, mitochondrial; Short=MRP-S7; Short=S7mt; AltName: Full=bMRP-27a; Short=bMRP27a; Flags: Precursor; SUBUNIT: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins (By similarity). SUBCELLULAR LOCATION: Mitochondrion (By similarity). SIMILARITY: Belongs to the ribosomal protein S7P family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y2R9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
