Human Gene BIRC5 (ENST00000301633.8) from GENCODE V44
Description: Homo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 3, mRNA. (from RefSeq NM_001012271) RefSeq Summary (NM_001012271): This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]. Gencode Transcript: ENST00000301633.8 Gencode Gene: ENSG00000089685.15 Transcript (Including UTRs) Position: hg38 chr17:78,214,186-78,225,636 Size: 11,451 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr17:78,214,317-78,223,554 Size: 9,238 Coding Exon Count: 5
ID:H3BLT4_HUMAN DESCRIPTION: SubName: Full=Baculoviral IAP repeat-containing protein 5; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00653 - Inhibitor of Apoptosis domain
ModBase Predicted Comparative 3D Structure on H3BLT4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0000226 microtubule cytoskeleton organization GO:0007346 regulation of mitotic cell cycle GO:0043066 negative regulation of apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061469 regulation of type B pancreatic cell proliferation
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