ID:TXND2_HUMAN DESCRIPTION: RecName: Full=Thioredoxin domain-containing protein 2; AltName: Full=Spermatid-specific thioredoxin-1; Short=Sptrx-1; FUNCTION: Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase. SUBCELLULAR LOCATION: Cytoplasm. Note=In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece. TISSUE SPECIFICITY: Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating spermatids. SIMILARITY: Contains 1 thioredoxin domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86VQ3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004791 thioredoxin-disulfide reductase activity GO:0015035 protein disulfide oxidoreductase activity GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0047134 protein-disulfide reductase activity
Biological Process: GO:0006662 glycerol ether metabolic process GO:0007275 multicellular organism development GO:0007283 spermatogenesis GO:0030154 cell differentiation GO:0034599 cellular response to oxidative stress GO:0045454 cell redox homeostasis GO:0055114 oxidation-reduction process GO:0098869 cellular oxidant detoxification
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