Human Gene PRELID3A (ENST00000440960.6) from GENCODE V44
  Description: Homo sapiens PRELI domain containing 3A (PRELID3A), transcript variant 2, mRNA. (from RefSeq NM_006553)
Gencode Transcript: ENST00000440960.6
Gencode Gene: ENSG00000141391.14
Transcript (Including UTRs)
   Position: hg38 chr18:12,407,929-12,432,234 Size: 24,306 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr18:12,407,976-12,429,403 Size: 21,428 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:12,407,929-12,432,234)mRNA (may differ from genome)Protein (172 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHPRD
LynxMGIneXtProtOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SLMO1_HUMAN
DESCRIPTION: RecName: Full=Protein slowmo homolog 1;
SIMILARITY: Belongs to the slowmo family.
SIMILARITY: Contains 1 PRELI/MSF1 domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.62 RPKM in Nerve - Tibial
Total median expression: 128.59 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.2047-0.451 Picture PostScript Text
3' UTR -466.601118-0.417 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006797 - PRELI/MSF1

Pfam Domains:
PF04707 - PRELI-like family

ModBase Predicted Comparative 3D Structure on Q96N28
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:1990050 phosphatidic acid transporter activity

Biological Process:
GO:0006869 lipid transport
GO:0015914 phospholipid transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space


-  Descriptions from all associated GenBank mRNAs
  KJ893101 - Synthetic construct Homo sapiens clone ccsbBroadEn_02495 SLMO1 gene, encodes complete protein.
KJ902141 - Synthetic construct Homo sapiens clone ccsbBroadEn_11535 SLMO1 gene, encodes complete protein.
LF385254 - JP 2014500723-A/192757: Polycomb-Associated Non-Coding RNAs.
MA620831 - JP 2018138019-A/192757: Polycomb-Associated Non-Coding RNAs.
AK056046 - Homo sapiens cDNA FLJ31484 fis, clone NT2NE2001697, weakly similar to MSF1 PROTEIN.
BC106750 - Homo sapiens slowmo homolog 1 (Drosophila), mRNA (cDNA clone MGC:120170 IMAGE:40022464), complete cds.
AK303325 - Homo sapiens cDNA FLJ57699 complete cds.
AL359942 - Homo sapiens mRNA; cDNA DKFZp547K106 (from clone DKFZp547K106).
CR627465 - Homo sapiens mRNA; cDNA DKFZp547K106 (from clone DKFZp547K106).
JD020250 - Sequence 1274 from Patent EP1572962.
JD032172 - Sequence 13196 from Patent EP1572962.
JD020818 - Sequence 1842 from Patent EP1572962.
BC007528 - Homo sapiens slowmo homolog 1 (Drosophila), mRNA (cDNA clone IMAGE:3346312).
JD023265 - Sequence 4289 from Patent EP1572962.
JD031010 - Sequence 12034 from Patent EP1572962.
JD026397 - Sequence 7421 from Patent EP1572962.
JD030484 - Sequence 11508 from Patent EP1572962.
JD453914 - Sequence 434938 from Patent EP1572962.
AF048849 - Homo sapiens erythroid differentiation and denucleation factor 1 (HFL-EDDG1) mRNA, complete cds.
JD131437 - Sequence 112461 from Patent EP1572962.
JD376986 - Sequence 358010 from Patent EP1572962.
JD424179 - Sequence 405203 from Patent EP1572962.
JD198196 - Sequence 179220 from Patent EP1572962.
BT007092 - Homo sapiens erythroid differentiation and denucleation factor 1 mRNA, complete cds.
JD494754 - Sequence 475778 from Patent EP1572962.
JD450235 - Sequence 431259 from Patent EP1572962.
JD300166 - Sequence 281190 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96N28 (Reactome details) participates in the following event(s):

R-HSA-6801242 TRIAP1 binds PRELID1, PRELID3A
R-HSA-6801250 TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B0YJ10, C18orf43, D3DUJ1, ENST00000440960.1, ENST00000440960.2, ENST00000440960.3, ENST00000440960.4, ENST00000440960.5, NM_006553, Q6AHX2, Q96N28, SLMO1, SLMO1_HUMAN, uc002kra.1, uc002kra.2, uc002kra.3, uc002kra.4, uc002kra.5
UCSC ID: ENST00000440960.6
RefSeq Accession: NM_001142405
Protein: Q96N28 (aka SLMO1_HUMAN)
CCDS: CCDS11860.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.