Human Gene ZBTB7C (ENST00000535628.6) from GENCODE V44
  Description: Homo sapiens zinc finger and BTB domain containing 7C (ZBTB7C), transcript variant 2, mRNA. (from RefSeq NM_001039360)
Gencode Transcript: ENST00000535628.6
Gencode Gene: ENSG00000184828.10
Transcript (Including UTRs)
   Position: hg38 chr18:48,026,673-48,137,361 Size: 110,689 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr18:48,029,260-48,041,107 Size: 11,848 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:48,026,673-48,137,361)mRNA (may differ from genome)Protein (619 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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HGNCHPRDLynxMGIOMIMPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: B2RG49_HUMAN
DESCRIPTION: SubName: Full=Zinc finger and BTB domain containing 7C;
SIMILARITY: Contains 1 BTB (POZ) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.96 RPKM in Esophagus - Mucosa
Total median expression: 124.98 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -153.40371-0.413 Picture PostScript Text
3' UTR -873.602587-0.338 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00651 - BTB/POZ domain

ModBase Predicted Comparative 3D Structure on B2RG49
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding

Biological Process:
GO:0045600 positive regulation of fat cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AM988839 - Homo sapiens mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.1.
AM998476 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.1.
AM998477 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.2.
AM998478 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.3.
AM998479 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.4.
AM998480 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.5.
AM998481 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.6.
AM998482 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.7.
AM998483 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.8.
AM998484 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.9.
AM998485 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.10.
AM998486 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.11.
AM998487 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.12.
AM991276 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.1.
AM991277 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.2.
AM991278 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.3.
AM991279 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.4.1.
AM991280 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.4.2.
AM991281 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.5.
AM991282 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.6.
AM991283 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.7.
AM991284 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.8.
AM991285 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.9.
AM989331 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.3.
EU669438 - Homo sapiens zinc finger and BTB domain-containing 7C (ZBTB7C) mRNA, partial cds.
AM989329 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.1.
AM989330 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.2.
AM989328 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-419.1.
AM991959 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.1.
AM991960 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.2.1.
AM991961 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.2.2.
AM991962 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.3.1.
AM991963 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.3.2.
AM991964 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.4.
AM991965 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.5.
AM991966 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.6.
AM991967 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.7.
AM991968 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.8.
AM991969 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.9.
AM991970 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.10.
AM988836 - Homo sapiens mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-391.1.
AM988837 - Homo sapiens mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-394.1.
AM988838 - Homo sapiens mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-394.2.
AK296709 - Homo sapiens cDNA FLJ60286 complete cds, highly similar to Homo sapiens zinc finger and BTB domain containing 7C (ZBTB7C), mRNA.
EF120357 - Homo sapiens zinc finger and BTB domain containing 7C (ZBTB7C) mRNA, complete cds.
AM998488 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-394.1.
AM998489 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-394.3.
AM989327 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-398.1.
AK095226 - Homo sapiens cDNA FLJ37907 fis, clone COLON2009337.
JD122507 - Sequence 103531 from Patent EP1572962.
JD295668 - Sequence 276692 from Patent EP1572962.
JD398071 - Sequence 379095 from Patent EP1572962.
JD412282 - Sequence 393306 from Patent EP1572962.
JD533615 - Sequence 514639 from Patent EP1572962.
JD040299 - Sequence 21323 from Patent EP1572962.
JD099854 - Sequence 80878 from Patent EP1572962.
JD284343 - Sequence 265367 from Patent EP1572962.
JD428893 - Sequence 409917 from Patent EP1572962.
JD356183 - Sequence 337207 from Patent EP1572962.
JD375766 - Sequence 356790 from Patent EP1572962.
JD270742 - Sequence 251766 from Patent EP1572962.
JD394485 - Sequence 375509 from Patent EP1572962.
JD458793 - Sequence 439817 from Patent EP1572962.
JD156358 - Sequence 137382 from Patent EP1572962.
JD323462 - Sequence 304486 from Patent EP1572962.
JD463642 - Sequence 444666 from Patent EP1572962.
JD438343 - Sequence 419367 from Patent EP1572962.
JD469057 - Sequence 450081 from Patent EP1572962.
JD539164 - Sequence 520188 from Patent EP1572962.
JD550510 - Sequence 531534 from Patent EP1572962.
JD359372 - Sequence 340396 from Patent EP1572962.
JD126603 - Sequence 107627 from Patent EP1572962.
JD473150 - Sequence 454174 from Patent EP1572962.
JD114976 - Sequence 96000 from Patent EP1572962.
JD471039 - Sequence 452063 from Patent EP1572962.
JD125862 - Sequence 106886 from Patent EP1572962.
JD209880 - Sequence 190904 from Patent EP1572962.
JD115549 - Sequence 96573 from Patent EP1572962.
JD464093 - Sequence 445117 from Patent EP1572962.
JD127478 - Sequence 108502 from Patent EP1572962.
BC167847 - Synthetic construct Homo sapiens clone IMAGE:100068237, MGC:195854 zinc finger and BTB domain containing 7C (ZBTB7C) mRNA, encodes complete protein.
AM989332 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-385.1.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RG49, B2RG49_HUMAN, ENST00000535628.1, ENST00000535628.2, ENST00000535628.3, ENST00000535628.4, ENST00000535628.5, NM_001039360, uc002ldb.1, uc002ldb.2, uc002ldb.3, uc002ldb.4
UCSC ID: ENST00000535628.6
RefSeq Accession: NM_001039360
Protein: B2RG49 CCDS: CCDS32830.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.