Human Gene RAB27B (uc002lfr.3) Description and Page Index
Description: Homo sapiens RAB27B, member RAS oncogene family (RAB27B), mRNA. RefSeq Summary (NM_004163): Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF329499.1, SRR1803612.60884.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262094.10/ ENSP00000262094.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr18:52,495,708-52,562,747 Size: 67,040 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr18:52,544,817-52,556,644 Size: 11,828 Coding Exon Count: 5
ID:RB27B_HUMAN DESCRIPTION: RecName: Full=Ras-related protein Rab-27B; AltName: Full=C25KG; FUNCTION: May be involved in targeting uroplakins to urothelial apical membranes (By similarity). SUBUNIT: Binds SYTL4 and MYRIP. Interacts with SYTL2 (By similarity). SUBCELLULAR LOCATION: Membrane; Lipid-anchor. TISSUE SPECIFICITY: Expressed primarily in testis. SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): RAB27B CDC HuGE Published Literature: RAB27B
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00194
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.