Human Gene GALR1 (ENST00000299727.5) from GENCODE V44
Description: Homo sapiens galanin receptor 1 (GALR1), mRNA. (from RefSeq NM_001480) RefSeq Summary (NM_001480): The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000299727.5 Gencode Gene: ENSG00000166573.6 Transcript (Including UTRs) Position: hg38 chr18:77,249,848-77,277,900 Size: 28,053 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr18:77,250,549-77,268,902 Size: 18,354 Coding Exon Count: 3
ID:GALR1_HUMAN DESCRIPTION: RecName: Full=Galanin receptor type 1; Short=GAL1-R; Short=GALR-1; FUNCTION: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. PTM: Palmitoylated on at least one of the three cysteine residues present in the C-terminal part. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P47211
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.