ID:ATP9B_HUMAN DESCRIPTION: RecName: Full=Probable phospholipid-transporting ATPase IIB; EC=3.6.3.1; AltName: Full=ATPase class II type 9B; CATALYTIC ACTIVITY: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out). SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B. SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. CAUTION: It is uncertain whether Met-1 or Met-53 is the initiator.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43861
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC036473 - Homo sapiens ATPase, class II, type 9B, mRNA (cDNA clone IMAGE:5259227), with apparent retained intron. AK308291 - Homo sapiens cDNA, FLJ98239. BC022535 - Homo sapiens ATPase, class II, type 9B, mRNA (cDNA clone IMAGE:4816928), with apparent retained intron. BC125220 - Homo sapiens ATPase, class II, type 9B, mRNA (cDNA clone MGC:150651 IMAGE:40123959), complete cds. BC125219 - Homo sapiens ATPase, class II, type 9B, mRNA (cDNA clone MGC:150650 IMAGE:40123958), complete cds. LF385265 - JP 2014500723-A/192768: Polycomb-Associated Non-Coding RNAs. MA620842 - JP 2018138019-A/192768: Polycomb-Associated Non-Coding RNAs. AK093704 - Homo sapiens cDNA FLJ36385 fis, clone THYMU2008727, highly similar to Probable phospholipid-transporting ATPase IIB (EC 3.6.3.1). AX748269 - Sequence 1794 from Patent EP1308459. AK097757 - Homo sapiens cDNA FLJ40438 fis, clone TESTI2039776, highly similar to POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE IIB (EC 3.6.1.-). AB373110 - Homo sapiens hMMR1 mRNA for macrophage MHC receptor 1, complete cds. BX537860 - Homo sapiens mRNA; cDNA DKFZp686H2093 (from clone DKFZp686H2093). BX648948 - Homo sapiens mRNA; cDNA DKFZp686F0648 (from clone DKFZp686F0648). AK295981 - Homo sapiens cDNA FLJ61123 complete cds, highly similar to Homo sapiens ATPase, Class II, type 9B (ATP9B), mRNA. BC053561 - Homo sapiens ATPase, class II, type 9B, mRNA (cDNA clone IMAGE:6164343), complete cds. CU690988 - Synthetic construct Homo sapiens gateway clone IMAGE:100021508 5' read ATP9B mRNA. KJ906492 - Synthetic construct Homo sapiens clone ccsbBroadEn_16162 ATP9B gene, encodes complete protein. LF344095 - JP 2014500723-A/151598: Polycomb-Associated Non-Coding RNAs. MA579672 - JP 2018138019-A/151598: Polycomb-Associated Non-Coding RNAs. LF344093 - JP 2014500723-A/151596: Polycomb-Associated Non-Coding RNAs. MA579670 - JP 2018138019-A/151596: Polycomb-Associated Non-Coding RNAs. LF344087 - JP 2014500723-A/151590: Polycomb-Associated Non-Coding RNAs. MA579664 - JP 2018138019-A/151590: Polycomb-Associated Non-Coding RNAs. LF344055 - JP 2014500723-A/151558: Polycomb-Associated Non-Coding RNAs. MA579632 - JP 2018138019-A/151558: Polycomb-Associated Non-Coding RNAs. LF344053 - JP 2014500723-A/151556: Polycomb-Associated Non-Coding RNAs. MA579630 - JP 2018138019-A/151556: Polycomb-Associated Non-Coding RNAs. LF344052 - JP 2014500723-A/151555: Polycomb-Associated Non-Coding RNAs. MA579629 - JP 2018138019-A/151555: Polycomb-Associated Non-Coding RNAs. LF344047 - JP 2014500723-A/151550: Polycomb-Associated Non-Coding RNAs. MA579624 - JP 2018138019-A/151550: Polycomb-Associated Non-Coding RNAs. LF344046 - JP 2014500723-A/151549: Polycomb-Associated Non-Coding RNAs. MA579623 - JP 2018138019-A/151549: Polycomb-Associated Non-Coding RNAs. AK127634 - Homo sapiens cDNA FLJ45732 fis, clone HSYRA2004550, highly similar to Potential phospholipid-transporting ATPase IIB (EC 3.6.3.13). LF344045 - JP 2014500723-A/151548: Polycomb-Associated Non-Coding RNAs. MA579622 - JP 2018138019-A/151548: Polycomb-Associated Non-Coding RNAs. U78978 - Homo sapiens putative ATPase mRNA, partial cds. BC037546 - Homo sapiens ATPase, class II, type 9B, mRNA (cDNA clone IMAGE:5206457), with apparent retained intron. AJ006268 - Homo sapiens mRNA for putative ATPase, partial. LF344043 - JP 2014500723-A/151546: Polycomb-Associated Non-Coding RNAs. MA579620 - JP 2018138019-A/151546: Polycomb-Associated Non-Coding RNAs. LF344042 - JP 2014500723-A/151545: Polycomb-Associated Non-Coding RNAs. MA579619 - JP 2018138019-A/151545: Polycomb-Associated Non-Coding RNAs. AK130499 - Homo sapiens cDNA FLJ26989 fis, clone SLV03395. LF344041 - JP 2014500723-A/151544: Polycomb-Associated Non-Coding RNAs. MA579618 - JP 2018138019-A/151544: Polycomb-Associated Non-Coding RNAs. AL096735 - Homo sapiens mRNA; cDNA DKFZp434A042 (from clone DKFZp434A042). LF344039 - JP 2014500723-A/151542: Polycomb-Associated Non-Coding RNAs. MA579616 - JP 2018138019-A/151542: Polycomb-Associated Non-Coding RNAs. JD106634 - Sequence 87658 from Patent EP1572962. JD218567 - Sequence 199591 from Patent EP1572962. JD382988 - Sequence 364012 from Patent EP1572962. JD393967 - Sequence 374991 from Patent EP1572962. JD057188 - Sequence 38212 from Patent EP1572962. JD455424 - Sequence 436448 from Patent EP1572962. JD156967 - Sequence 137991 from Patent EP1572962. JD156966 - Sequence 137990 from Patent EP1572962. JD455307 - Sequence 436331 from Patent EP1572962. JD457595 - Sequence 438619 from Patent EP1572962. JD156965 - Sequence 137989 from Patent EP1572962. JD455307 - Sequence 436331 from Patent EP1572962. JD368854 - Sequence 349878 from Patent EP1572962. JD232913 - Sequence 213937 from Patent EP1572962. JD513685 - Sequence 494709 from Patent EP1572962. JD354536 - Sequence 335560 from Patent EP1572962. JD538723 - Sequence 519747 from Patent EP1572962. JD156966 - Sequence 137990 from Patent EP1572962. JD156967 - Sequence 137991 from Patent EP1572962. JD455307 - Sequence 436331 from Patent EP1572962. JD074410 - Sequence 55434 from Patent EP1572962. JD152613 - Sequence 133637 from Patent EP1572962. JD412230 - Sequence 393254 from Patent EP1572962. JD084643 - Sequence 65667 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O43861 (Reactome details) participates in the following event(s):
R-HSA-939763 P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane R-HSA-947591 P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane R-HSA-936837 Ion transport by P-type ATPases R-HSA-983712 Ion channel transport R-HSA-382551 Transport of small molecules