Human Gene R3HDM4 (ENST00000361574.10) from GENCODE V44
  Description: Homo sapiens R3H domain containing 4 (R3HDM4), mRNA. (from RefSeq NM_138774)
Gencode Transcript: ENST00000361574.10
Gencode Gene: ENSG00000198858.10
Transcript (Including UTRs)
   Position: hg38 chr19:896,503-913,219 Size: 16,717 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr19:897,437-913,157 Size: 15,721 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:896,503-913,219)mRNA (may differ from genome)Protein (268 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: R3HD4_HUMAN
DESCRIPTION: RecName: Full=R3H domain-containing protein 4;
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Contains 1 R3H domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 376.19 RPKM in Whole Blood
Total median expression: 1569.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.2062-0.519 Picture PostScript Text
3' UTR -349.00934-0.374 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025952 - R3H-assoc_dom
IPR001374 - R3H_ss-bd

Pfam Domains:
PF13902 - R3H-associated N-terminal domain

ModBase Predicted Comparative 3D Structure on Q96D70
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI Ensembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK024622 - Homo sapiens cDNA: FLJ20969 fis, clone ADSU01403.
AK000263 - Homo sapiens cDNA FLJ20256 fis, clone COLF7180.
BC012775 - Homo sapiens chromosome 19 open reading frame 22, mRNA (cDNA clone IMAGE:3926175).
JD224066 - Sequence 205090 from Patent EP1572962.
JD466725 - Sequence 447749 from Patent EP1572962.
JD265277 - Sequence 246301 from Patent EP1572962.
JD105370 - Sequence 86394 from Patent EP1572962.
JD104597 - Sequence 85621 from Patent EP1572962.
JD337422 - Sequence 318446 from Patent EP1572962.
JD310698 - Sequence 291722 from Patent EP1572962.
JD530358 - Sequence 511382 from Patent EP1572962.
JD208402 - Sequence 189426 from Patent EP1572962.
JD488226 - Sequence 469250 from Patent EP1572962.
JD289232 - Sequence 270256 from Patent EP1572962.
JD387338 - Sequence 368362 from Patent EP1572962.
JD129833 - Sequence 110857 from Patent EP1572962.
DL492536 - Novel nucleic acids.
DL491005 - Novel nucleic acids.
JD547177 - Sequence 528201 from Patent EP1572962.
JD540221 - Sequence 521245 from Patent EP1572962.
JD278798 - Sequence 259822 from Patent EP1572962.
JD240160 - Sequence 221184 from Patent EP1572962.
JD389557 - Sequence 370581 from Patent EP1572962.
JD400596 - Sequence 381620 from Patent EP1572962.
JD075316 - Sequence 56340 from Patent EP1572962.
JD118727 - Sequence 99751 from Patent EP1572962.
JD193942 - Sequence 174966 from Patent EP1572962.
JD272517 - Sequence 253541 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C19orf22, ENST00000361574.1, ENST00000361574.2, ENST00000361574.3, ENST00000361574.4, ENST00000361574.5, ENST00000361574.6, ENST00000361574.7, ENST00000361574.8, ENST00000361574.9, NM_138774, Q96D70, R3HD4_HUMAN, uc002lqg.1, uc002lqg.2, uc002lqg.3, uc002lqg.4
UCSC ID: ENST00000361574.10
RefSeq Accession: NM_138774
Protein: Q96D70 (aka R3HD4_HUMAN)
CCDS: CCDS12048.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.