Human Gene ARID3A (ENST00000263620.8) from GENCODE V44
Description: Homo sapiens AT-rich interaction domain 3A (ARID3A), mRNA. (from RefSeq NM_005224) RefSeq Summary (NM_005224): This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000263620.8 Gencode Gene: ENSG00000116017.11 Transcript (Including UTRs) Position: hg38 chr19:926,035-975,939 Size: 49,905 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr19:929,529-972,065 Size: 42,537 Coding Exon Count: 8
ID:ARI3A_HUMAN DESCRIPTION: RecName: Full=AT-rich interactive domain-containing protein 3A; Short=ARID domain-containing protein 3A; AltName: Full=B-cell regulator of IgH transcription; Short=Bright; AltName: Full=Dead ringer-like protein 1; AltName: Full=E2F-binding protein 1; FUNCTION: Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. SUBUNIT: Homodimer. Heterodimer with ARID3B. Interacts with E2F1. Interacts with GTF2I and BTK. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm. TISSUE SPECIFICITY: Widely expressed, with highest expression in skeletal muscle, thalamus, and colon. INDUCTION: By p53/TP53 following DNA damage. SIMILARITY: Contains 1 ARID domain. SIMILARITY: Contains 1 REKLES domain. SEQUENCE CAUTION: Sequence=AAW30734.1; Type=Frameshift; Positions=498;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99856
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0042803 protein homodimerization activity
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0045944 positive regulation of transcription from RNA polymerase II promoter
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