Human Gene PCSK4 (ENST00000300954.10) from GENCODE V44
Description: Homo sapiens proprotein convertase subtilisin/kexin type 4 (PCSK4), mRNA. (from RefSeq NM_017573) RefSeq Summary (NM_017573): This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. The protease is expressed only in the testis, placenta, and ovary. It plays a critical role in fertilization, fetoplacental growth, and embryonic development and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein and pro-insulin-like growth factor II. [provided by RefSeq, Jan 2014]. Gencode Transcript: ENST00000300954.10 Gencode Gene: ENSG00000115257.15 Transcript (Including UTRs) Position: hg38 chr19:1,481,428-1,490,350 Size: 8,923 Total Exon Count: 15 Strand: - Coding Region Position: hg38 chr19:1,481,759-1,490,346 Size: 8,588 Coding Exon Count: 15
ID:PCSK4_HUMAN DESCRIPTION: RecName: Full=Proprotein convertase subtilisin/kexin type 4; EC=3.4.21.-; AltName: Full=Proprotein convertase 4; Short=PC4; Flags: Precursor; FUNCTION: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex. SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). TISSUE SPECIFICITY: Placenta. DEVELOPMENTAL STAGE: Localized predominantly in the cytotrophoblast layer of trophoblast cells during the first trimester of pregnancy, and to the syncytiotrophoblast and stroma cells during the third trimester. SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily. SIMILARITY: Contains 1 FU (furin-like) repeat.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6UW60
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
