Human Gene THOP1 (ENST00000307741.11) from GENCODE V44
Description: Homo sapiens thimet oligopeptidase 1 (THOP1), mRNA. (from RefSeq NM_003249) RefSeq Summary (NM_003249): The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]. Gencode Transcript: ENST00000307741.11 Gencode Gene: ENSG00000172009.15 Transcript (Including UTRs) Position: hg38 chr19:2,785,503-2,815,807 Size: 30,305 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr19:2,785,663-2,813,276 Size: 27,614 Coding Exon Count: 13
ID:THOP1_HUMAN DESCRIPTION: RecName: Full=Thimet oligopeptidase; EC=3.4.24.15; AltName: Full=Endopeptidase 24.15; AltName: Full=MP78; FUNCTION: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. CATALYTIC ACTIVITY: Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues. COFACTOR: Binds 1 zinc ion per subunit. SUBUNIT: Monomer (By similarity). INTERACTION: Q99547:MPHOSPH6; NbExp=1; IntAct=EBI-372399, EBI-373187; SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the peptidase M3 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P52888
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
