Human Gene SIRT6 (ENST00000337491.7) from GENCODE V44
Description: Homo sapiens sirtuin 6 (SIRT6), transcript variant 1, mRNA. (from RefSeq NM_016539) RefSeq Summary (NM_016539): This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]. Gencode Transcript: ENST00000337491.7 Gencode Gene: ENSG00000077463.15 Transcript (Including UTRs) Position: hg38 chr19:4,174,109-4,182,563 Size: 8,455 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr19:4,174,617-4,182,539 Size: 7,923 Coding Exon Count: 8
ID:SIR6_HUMAN DESCRIPTION: RecName: Full=NAD-dependent protein deacetylase sirtuin-6; EC=3.5.1.-; AltName: Full=Regulatory protein SIR2 homolog 6; AltName: Full=SIR2-like protein 6; FUNCTION: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. CATALYTIC ACTIVITY: NAD(+) + an acetylprotein = nicotinamide + O- acetyl-ADP-ribose + a protein. COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBUNIT: Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8. INTERACTION: Q04206:RELA; NbExp=4; IntAct=EBI-712415, EBI-73886; SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Note=Predominantly nuclear. Associated with telomeric heterochromatin regions. MISCELLANEOUS: The reported ADP-ribosyltransferase activity of sirtuins is likely some inefficient side reaction of the deacetylase activity and may not be physiologically relevant (By similarity). SIMILARITY: Belongs to the sirtuin family. Class IV subfamily. SIMILARITY: Contains 1 deacetylase sirtuin-type domain. SEQUENCE CAUTION: Sequence=AAC34468.1; Type=Erroneous gene model prediction; Sequence=AAD15478.1; Type=Erroneous gene model prediction; Sequence=AAH04218.1; Type=Erroneous translation; Note=Wrong choice of CCDS;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N6T7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.