Human Gene KRI1 (ENST00000312962.12) from GENCODE V44
  Description: Homo sapiens KRI1 homolog (KRI1), mRNA. (from RefSeq NM_023008)
RefSeq Summary (NM_023008): This gene overlaps with the gene for cysteine endopeptidase AUT-like 4 in a head-to-tail orientation. [provided by RefSeq, Jul 2008]. CCDS Note: The coding region has been updated to shorten the N-terminus to one that is more supported by conservation.
Gencode Transcript: ENST00000312962.12
Gencode Gene: ENSG00000129347.21
Transcript (Including UTRs)
   Position: hg38 chr19:10,553,085-10,566,010 Size: 12,926 Total Exon Count: 19 Strand: -
Coding Region
   Position: hg38 chr19:10,553,951-10,565,999 Size: 12,049 Coding Exon Count: 19 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:10,553,085-10,566,010)mRNA (may differ from genome)Protein (703 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KRI1_HUMAN
DESCRIPTION: RecName: Full=Protein KRI1 homolog;
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the KRI1 family.
SEQUENCE CAUTION: Sequence=BAB15278.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.05 RPKM in Testis
Total median expression: 602.54 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -322.00866-0.372 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024626 - Kri1-like_C
IPR018034 - KRR1-interact_protein_1

Pfam Domains:
PF05178 - KRI1-like family
PF12936 - KRI1-like family C-terminal

ModBase Predicted Comparative 3D Structure on Q8N9T8
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence 
AlignmentAlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding

Biological Process:
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Cellular Component:
GO:0005730 nucleolus
GO:0030686 90S preribosome


-  Descriptions from all associated GenBank mRNAs
  AL833189 - Homo sapiens mRNA; cDNA DKFZp667K055 (from clone DKFZp667K055).
AK097181 - Homo sapiens cDNA FLJ39862 fis, clone SPLEN2015166.
JD308846 - Sequence 289870 from Patent EP1572962.
JD530954 - Sequence 511978 from Patent EP1572962.
JD281092 - Sequence 262116 from Patent EP1572962.
JD099584 - Sequence 80608 from Patent EP1572962.
JD144803 - Sequence 125827 from Patent EP1572962.
BC009876 - Homo sapiens KRI1 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:3949107), partial cds.
AK025907 - Homo sapiens cDNA: FLJ22254 fis, clone HRC02778.
BC002890 - Homo sapiens KRI1 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:3942403), partial cds.
BC009303 - Homo sapiens KRI1 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:4128574), with apparent retained intron.
JD401894 - Sequence 382918 from Patent EP1572962.
AK023011 - Homo sapiens cDNA FLJ12949 fis, clone NT2RP2005336, weakly similar to TRICHOHYALIN.
AK300780 - Homo sapiens cDNA FLJ53206 complete cds.
AK093879 - Homo sapiens cDNA FLJ36560 fis, clone TRACH2009340.
AX748348 - Sequence 1873 from Patent EP1308459.
JD366317 - Sequence 347341 from Patent EP1572962.
JD411210 - Sequence 392234 from Patent EP1572962.
JD061454 - Sequence 42478 from Patent EP1572962.
JD247718 - Sequence 228742 from Patent EP1572962.
JD324524 - Sequence 305548 from Patent EP1572962.
JD079498 - Sequence 60522 from Patent EP1572962.
JD243189 - Sequence 224213 from Patent EP1572962.
JD112164 - Sequence 93188 from Patent EP1572962.
JD089348 - Sequence 70372 from Patent EP1572962.
JD277684 - Sequence 258708 from Patent EP1572962.
JD117479 - Sequence 98503 from Patent EP1572962.
JD139120 - Sequence 120144 from Patent EP1572962.
JD102003 - Sequence 83027 from Patent EP1572962.
JD481444 - Sequence 462468 from Patent EP1572962.
JD249312 - Sequence 230336 from Patent EP1572962.
JD146918 - Sequence 127942 from Patent EP1572962.
BC112249 - Homo sapiens KRI1 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:8327717), partial cds.
BC112251 - Homo sapiens KRI1 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:8327719), partial cds.
BC143770 - Homo sapiens KRI1 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:9052284), partial cds.
JD107800 - Sequence 88824 from Patent EP1572962.
JD205547 - Sequence 186571 from Patent EP1572962.
BC166660 - Synthetic construct Homo sapiens clone IMAGE:100066386, MGC:195523 KRI1 homolog (S. cerevisiae) (KRI1) mRNA, encodes complete protein.
AK300850 - Homo sapiens cDNA FLJ56362 complete cds.
LF208686 - JP 2014500723-A/16189: Polycomb-Associated Non-Coding RNAs.
MA444263 - JP 2018138019-A/16189: Polycomb-Associated Non-Coding RNAs.
LF378972 - JP 2014500723-A/186475: Polycomb-Associated Non-Coding RNAs.
MA614549 - JP 2018138019-A/186475: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000312962.1, ENST00000312962.10, ENST00000312962.11, ENST00000312962.2, ENST00000312962.3, ENST00000312962.4, ENST00000312962.5, ENST00000312962.6, ENST00000312962.7, ENST00000312962.8, ENST00000312962.9, KRI1_HUMAN, NM_023008, Q2M1R5, Q2M1R7, Q7L5J7, Q8N9T8, Q96G92, Q9BU50, Q9H6I1, Q9H978, uc002moy.1, uc002moy.2, uc002moy.3
UCSC ID: ENST00000312962.12
RefSeq Accession: NM_023008
Protein: Q8N9T8 (aka KRI1_HUMAN)
CCDS: CCDS12242.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.