Human Gene F2RL3 (ENST00000248076.4) from GENCODE V44
Description: Homo sapiens F2R like thrombin or trypsin receptor 3 (F2RL3), mRNA. (from RefSeq NM_003950) RefSeq Summary (NM_003950): This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]. Gencode Transcript: ENST00000248076.4 Gencode Gene: ENSG00000127533.4 Transcript (Including UTRs) Position: hg38 chr19:16,888,999-16,892,606 Size: 3,608 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr19:16,889,190-16,890,621 Size: 1,432 Coding Exon Count: 2
ID:PAR4_HUMAN DESCRIPTION: RecName: Full=Proteinase-activated receptor 4; Short=PAR-4; AltName: Full=Coagulation factor II receptor-like 3; AltName: Full=Thrombin receptor-like 3; Flags: Precursor; FUNCTION: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets. PTM: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/f2rl3/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96RI0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.