Human Gene NXNL1 (ENST00000301944.3) from GENCODE V44
Description: Homo sapiens nucleoredoxin like 1 (NXNL1), mRNA. (from RefSeq NM_138454) RefSeq Summary (NM_138454): Retinitis pigmentosa (RP) is a disease that leads to blindness by degeneration of cone photoreceptors. Rods produce factors required for cone viability. The protein encoded by this gene is one of those factors and is similar to a truncated form of thioredoxin. This gene has been proposed to have therapeutic value against RP. [provided by RefSeq, Dec 2015]. Gencode Transcript: ENST00000301944.3 Gencode Gene: ENSG00000171773.3 Transcript (Including UTRs) Position: hg38 chr19:17,455,425-17,460,926 Size: 5,502 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr19:17,455,647-17,460,869 Size: 5,223 Coding Exon Count: 2
ID:NXNL1_HUMAN DESCRIPTION: RecName: Full=Nucleoredoxin-like protein 1; AltName: Full=Thioredoxin-like protein 6; FUNCTION: May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity). SUBCELLULAR LOCATION: Nucleus outer membrane (By similarity). SIMILARITY: Belongs to the nucleoredoxin family. SIMILARITY: Contains 1 thioredoxin domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96CM4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.