Human Gene RPL18A (ENST00000222247.10) from GENCODE V44
Description: Homo sapiens ribosomal protein L18a (RPL18A), mRNA. (from RefSeq NM_000980) RefSeq Summary (NM_000980): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]. Gencode Transcript: ENST00000222247.10 Gencode Gene: ENSG00000105640.13 Transcript (Including UTRs) Position: hg38 chr19:17,859,910-17,863,319 Size: 3,410 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr19:17,859,957-17,863,263 Size: 3,307 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q02543
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC066319 - Homo sapiens ribosomal protein L18a, mRNA (cDNA clone MGC:87208 IMAGE:5286436), complete cds. AK297323 - Homo sapiens cDNA FLJ51501 complete cds, highly similar to 60S ribosomal protein L18a. D28393 - Homo sapiens mRNA for ribosomal protein L18a, 5'UTR region. AK311774 - Homo sapiens cDNA, FLJ92035, highly similar to Homo sapiens ribosomal protein L18a (RPL18A), mRNA. AK222647 - Homo sapiens mRNA for ribosomal protein L18a variant, clone: CBL08590. AK297358 - Homo sapiens cDNA FLJ51502 complete cds, highly similar to 60S ribosomal protein L18a. AK300809 - Homo sapiens cDNA FLJ52166 complete cds, highly similar to 60S ribosomal protein L18a. BC007512 - Homo sapiens ribosomal protein L18a, mRNA (cDNA clone MGC:4476 IMAGE:2961519), complete cds. L05093 - Homo sapiens ribosomal protein L18a mRNA, complete cds. BC071920 - Homo sapiens ribosomal protein L18a, mRNA (cDNA clone MGC:88602 IMAGE:6293838), complete cds. X80822 - H.sapiens mRNA for ORF. AB528676 - Synthetic construct DNA, clone: pF1KB6847, Homo sapiens RPL18A gene for ribosomal protein L18a, without stop codon, in Flexi system. CU688140 - Synthetic construct Homo sapiens gateway clone IMAGE:100022940 5' read RPL18A mRNA. HQ447470 - Synthetic construct Homo sapiens clone IMAGE:100070799; CCSB014532_02 ribosomal protein L18a (RPL18A) gene, encodes complete protein. JF432574 - Synthetic construct Homo sapiens clone IMAGE:100073809 ribosomal protein L18a (RPL18A) gene, encodes complete protein. KJ897489 - Synthetic construct Homo sapiens clone ccsbBroadEn_06883 RPL18A gene, encodes complete protein. DQ600380 - Homo sapiens piRNA piR-38446, complete sequence. DQ593295 - Homo sapiens piRNA piR-33407, complete sequence. JD026710 - Sequence 7734 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03010 - Ribosome
Reactome (by CSHL, EBI, and GO)
Protein Q02543 (Reactome details) participates in the following event(s):
R-HSA-72672 The 60S subunit joins the translation initiation complex R-HSA-156826 Dissociation of L13a from the 60s ribosomal subunit R-HSA-72673 Release of 40S and 60S subunits from the 80S ribosome R-HSA-72671 eIF5B:GTP is hydrolyzed and released R-HSA-156907 Aminoacyl-tRNA binds to the ribosome at the A-site R-HSA-2408529 Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex R-HSA-156915 Translocation of ribosome by 3 bases in the 3' direction R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) R-HSA-156923 Hydrolysis of eEF1A:GTP R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-156827 L13a-mediated translation R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-72737 Cap-dependent Translation Initiation R-HSA-72613 Eukaryotic Translation Initiation R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-156902 Peptide chain elongation R-HSA-2408557 Selenocysteine synthesis R-HSA-72764 Eukaryotic Translation Termination R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-72766 Translation R-HSA-376176 Signaling by ROBO receptors R-HSA-192823 Viral mRNA Translation R-HSA-72312 rRNA processing R-HSA-156842 Eukaryotic Translation Elongation R-HSA-2408522 Selenoamino acid metabolism R-HSA-927802 Nonsense-Mediated Decay (NMD) R-HSA-392499 Metabolism of proteins R-HSA-422475 Axon guidance R-HSA-168273 Influenza Viral RNA Transcription and Replication R-HSA-8953854 Metabolism of RNA R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-1266738 Developmental Biology R-HSA-168255 Influenza Life Cycle R-HSA-1430728 Metabolism R-HSA-168254 Influenza Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
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