Human Gene PDE4C (ENST00000262805.17) from GENCODE V44
Description: Homo sapiens phosphodiesterase 4C (PDE4C), transcript variant 3, mRNA. (from RefSeq NM_001098818) RefSeq Summary (NM_001098818): The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]. Gencode Transcript: ENST00000262805.17 Gencode Gene: ENSG00000105650.23 Transcript (Including UTRs) Position: hg38 chr19:18,207,965-18,226,438 Size: 18,474 Total Exon Count: 15 Strand: - Coding Region Position: hg38 chr19:18,210,929-18,226,415 Size: 15,487 Coding Exon Count: 15
ID:PDE4C_HUMAN DESCRIPTION: RecName: Full=cAMP-specific 3',5'-cyclic phosphodiesterase 4C; EC=3.1.4.17; AltName: Full=DPDE1; AltName: Full=PDE21; FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. CATALYTIC ACTIVITY: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate. COFACTOR: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ENZYME REGULATION: Inhibited by rolipram. PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. SUBUNIT: Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2 (By similarity). SUBCELLULAR LOCATION: Cell projection, cilium (By similarity). TISSUE SPECIFICITY: Expressed in various tissues but not in cells of the immune system. SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q08493
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
