Human Gene COPE (ENST00000262812.9) from GENCODE V44
Description: Homo sapiens COPI coat complex subunit epsilon (COPE), transcript variant 1, mRNA. (from RefSeq NM_007263) RefSeq Summary (NM_007263): The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000262812.9 Gencode Gene: ENSG00000105669.14 Transcript (Including UTRs) Position: hg38 chr19:18,899,514-18,919,387 Size: 19,874 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr19:18,899,679-18,919,348 Size: 19,670 Coding Exon Count: 10
ID:COPE_HUMAN DESCRIPTION: RecName: Full=Coatomer subunit epsilon; AltName: Full=Epsilon-coat protein; Short=Epsilon-COP; FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). SUBUNIT: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). PTM: Phosphorylated by PKA. PTM: Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation. SIMILARITY: Belongs to the COPE family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14579
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005198 structural molecule activity GO:0005515 protein binding
Biological Process: GO:0006888 ER to Golgi vesicle-mediated transport GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0006891 intra-Golgi vesicle-mediated transport GO:0015031 protein transport GO:0016192 vesicle-mediated transport
AL136928 - Homo sapiens mRNA; cDNA DKFZp586A1622 (from clone DKFZp586A1622). BC007250 - Homo sapiens coatomer protein complex, subunit epsilon, mRNA (cDNA clone MGC:15494 IMAGE:2989183), complete cds. AK222584 - Homo sapiens mRNA for epsilon subunit of coatomer protein complex isoform a variant, clone: CAS04232. AF092438 - Homo sapiens epsilon-COP mRNA, complete cds. BC052619 - Homo sapiens coatomer protein complex, subunit epsilon, mRNA (cDNA clone IMAGE:6580357), with apparent retained intron. BC017285 - Homo sapiens coatomer protein complex, subunit epsilon, mRNA (cDNA clone MGC:29652 IMAGE:4891380), complete cds. BC003155 - Homo sapiens coatomer protein complex, subunit epsilon, mRNA (cDNA clone MGC:4118 IMAGE:2906127), complete cds. AJ249366 - Homo sapiens mRNA for epsilon-COP protein and epsilon-COP protein. AJ131182 - Homo sapiens mRNA for Epsilon COP. JD436821 - Sequence 417845 from Patent EP1572962. JD310029 - Sequence 291053 from Patent EP1572962. AK315281 - Homo sapiens cDNA, FLJ96293, Homo sapiens coatomer protein complex, subunit epsilon (COPE), mRNA. KJ898403 - Synthetic construct Homo sapiens clone ccsbBroadEn_07797 COPE gene, encodes complete protein. DQ893417 - Synthetic construct clone IMAGE:100006047; FLH199498.01X; RZPDo839E0682D coatomer protein complex, subunit epsilon (COPE) gene, encodes complete protein. DQ896735 - Synthetic construct Homo sapiens clone IMAGE:100011195; FLH199404.01L; RZPDo839E0681D coatomer protein complex, subunit epsilon (COPE) gene, encodes complete protein. AB528108 - Synthetic construct DNA, clone: pF1KE0114, Homo sapiens COPE gene for coatomer protein complex, subunit epsilon, without stop codon, in Flexi system. AM393761 - Synthetic construct Homo sapiens clone IMAGE:100001833 for hypothetical protein (COPE gene). CR456886 - Homo sapiens full open reading frame cDNA clone RZPDo834E0818D for gene COPE, coatomer protein complex, subunit epsilon; complete cds, incl. stopcodon. AK023303 - Homo sapiens cDNA FLJ13241 fis, clone OVARC1000557. JD071717 - Sequence 52741 from Patent EP1572962. JD023541 - Sequence 4565 from Patent EP1572962. JD023542 - Sequence 4566 from Patent EP1572962. JD035975 - Sequence 16999 from Patent EP1572962. JD026235 - Sequence 7259 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O14579 (Reactome details) participates in the following event(s):
R-HSA-6807872 Active ARF recruits coatomer R-HSA-6811412 Active ARF recruits coatomer to the Golgi R-HSA-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex R-HSA-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-6807877 ARFGAPs stimulate ARF GTPase activity R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
