Human Gene ZNF429 (ENST00000358491.9) from GENCODE V44
  Description: Homo sapiens zinc finger protein 429 (ZNF429), transcript variant 6, mRNA. (from RefSeq NM_001346916)
Gencode Transcript: ENST00000358491.9
Gencode Gene: ENSG00000197013.11
Transcript (Including UTRs)
   Position: hg38 chr19:21,505,602-21,540,668 Size: 35,067 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr19:21,505,772-21,538,078 Size: 32,307 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:21,505,602-21,540,668)mRNA (may differ from genome)Protein (674 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN429_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 429;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Contains 18 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=AAK01422.1; Type=Frameshift; Positions=Several; Sequence=AAK01422.1; Type=Miscellaneous discrepancy; Sequence=AAP30884.1; Type=Frameshift; Positions=Several; Sequence=AAP30884.1; Type=Miscellaneous discrepancy;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.55 RPKM in Testis
Total median expression: 63.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -62.60170-0.368 Picture PostScript Text
3' UTR -824.002590-0.318 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF01352 - KRAB box

ModBase Predicted Comparative 3D Structure on Q86V71
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK308708 - Homo sapiens cDNA, FLJ98749.
AF325191 - Homo sapiens KRAB zinc finger protein HZF26 (HZF26) mRNA, partial cds.
AY269786 - Homo sapiens zinc finger protein 429 (ZNF429) mRNA, complete cds.
JD340209 - Sequence 321233 from Patent EP1572962.
JD196805 - Sequence 177829 from Patent EP1572962.
BC156455 - Synthetic construct Homo sapiens clone IMAGE:100063050, MGC:190675 zinc finger protein 429 (ZNF429) mRNA, encodes complete protein.
BC172531 - Synthetic construct Homo sapiens clone IMAGE:100069225, MGC:199236 zinc finger protein 429 (ZNF429) mRNA, encodes complete protein.
JD342502 - Sequence 323526 from Patent EP1572962.
JD480600 - Sequence 461624 from Patent EP1572962.
JD172094 - Sequence 153118 from Patent EP1572962.
JD303598 - Sequence 284622 from Patent EP1572962.
JD314882 - Sequence 295906 from Patent EP1572962.
JD330621 - Sequence 311645 from Patent EP1572962.
JD314888 - Sequence 295912 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
JD330516 - Sequence 311540 from Patent EP1572962.
JD066994 - Sequence 48018 from Patent EP1572962.
JD314888 - Sequence 295912 from Patent EP1572962.
DQ596756 - Homo sapiens piRNA piR-34822, complete sequence.
JD257035 - Sequence 238059 from Patent EP1572962.
JD294133 - Sequence 275157 from Patent EP1572962.
JD421495 - Sequence 402519 from Patent EP1572962.
JD179108 - Sequence 160132 from Patent EP1572962.
JD366668 - Sequence 347692 from Patent EP1572962.
JD366667 - Sequence 347691 from Patent EP1572962.
JD366666 - Sequence 347690 from Patent EP1572962.
JD113366 - Sequence 94390 from Patent EP1572962.
JD517905 - Sequence 498929 from Patent EP1572962.
JD219964 - Sequence 200988 from Patent EP1572962.
JD216169 - Sequence 197193 from Patent EP1572962.
JD497813 - Sequence 478837 from Patent EP1572962.
JD410084 - Sequence 391108 from Patent EP1572962.
JD154625 - Sequence 135649 from Patent EP1572962.
JD083196 - Sequence 64220 from Patent EP1572962.
JD083195 - Sequence 64219 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86V71 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A6NLV7, ENST00000358491.1, ENST00000358491.2, ENST00000358491.3, ENST00000358491.4, ENST00000358491.5, ENST00000358491.6, ENST00000358491.7, ENST00000358491.8, NM_001346916, Q86V71, Q9BZE6, uc002nqd.1, uc002nqd.2, uc002nqd.3, ZN429_HUMAN
UCSC ID: ENST00000358491.9
RefSeq Accession: NM_001001415
Protein: Q86V71 (aka ZN429_HUMAN or Z429_HUMAN)
CCDS: CCDS42537.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.