Human Gene PPP1R14A (ENST00000301242.9) from GENCODE V44
Description: Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), transcript variant 1, mRNA. (from RefSeq NM_033256) RefSeq Summary (NM_033256): The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]. Gencode Transcript: ENST00000301242.9 Gencode Gene: ENSG00000167641.11 Transcript (Including UTRs) Position: hg38 chr19:38,251,237-38,256,374 Size: 5,138 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr19:38,251,318-38,256,339 Size: 5,022 Coding Exon Count: 4
ID:PP14A_HUMAN DESCRIPTION: RecName: Full=Protein phosphatase 1 regulatory subunit 14A; AltName: Full=17 kDa PKC-potentiated inhibitory protein of PP1; AltName: Full=Protein kinase C-potentiated inhibitor protein of 17 kDa; Short=CPI-17; FUNCTION: Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. SIMILARITY: Belongs to the PP1 inhibitor family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05361 - PKC-activated protein phosphatase-1 inhibitor
ModBase Predicted Comparative 3D Structure on Q96A00
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004864 protein phosphatase inhibitor activity
Biological Process: GO:0032515 negative regulation of phosphoprotein phosphatase activity GO:0035690 cellular response to drug GO:0042325 regulation of phosphorylation
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