Human Gene SIRT2 (ENST00000249396.12) from GENCODE V44
Description: Homo sapiens sirtuin 2 (SIRT2), transcript variant 1, mRNA. (from RefSeq NM_012237) RefSeq Summary (NM_012237): This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]. Gencode Transcript: ENST00000249396.12 Gencode Gene: ENSG00000068903.21 Transcript (Including UTRs) Position: hg38 chr19:38,878,560-38,899,618 Size: 21,059 Total Exon Count: 16 Strand: - Coding Region Position: hg38 chr19:38,879,155-38,899,521 Size: 20,367 Coding Exon Count: 16
ID:SIR2_HUMAN DESCRIPTION: RecName: Full=NAD-dependent protein deacetylase sirtuin-2; EC=3.5.1.-; AltName: Full=Regulatory protein SIR2 homolog 2; AltName: Full=SIR2-like protein 2; FUNCTION: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA. CATALYTIC ACTIVITY: NAD(+) + an acetylprotein = nicotinamide + O- acetyl-ADP-ribose + a protein. COFACTOR: Binds 1 zinc ion per subunit. ENZYME REGULATION: Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide. SUBUNIT: Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton. INTERACTION: Q12834:CDC20; NbExp=2; IntAct=EBI-5240785, EBI-367462; Q9UM11:FZR1; NbExp=2; IntAct=EBI-5240785, EBI-724997; Q92831:KAT2B; NbExp=4; IntAct=EBI-477232, EBI-477430; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. TISSUE SPECIFICITY: Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. DEVELOPMENTAL STAGE: Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome. PTM: Phosphorylated at the G2/M transition of the cell cycle. MISCELLANEOUS: Has some ability to deacetylate histones in vitro, but seeing its subcellular location, this is unlikely in vivo. SIMILARITY: Belongs to the sirtuin family. Class I subfamily. SIMILARITY: Contains 1 deacetylase sirtuin-type domain. SEQUENCE CAUTION: Sequence=AAD45971.1; Type=Erroneous initiation; Sequence=AAF67015.1; Type=Frameshift; Positions=Several;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IXJ6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0000183 chromatin silencing at rDNA GO:0002376 immune system process GO:0006342 chromatin silencing GO:0006348 chromatin silencing at telomere GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006471 protein ADP-ribosylation GO:0006476 protein deacetylation GO:0006914 autophagy GO:0007049 cell cycle GO:0007096 regulation of exit from mitosis GO:0007399 nervous system development GO:0008285 negative regulation of cell proliferation GO:0010507 negative regulation of autophagy GO:0010801 negative regulation of peptidyl-threonine phosphorylation GO:0014065 phosphatidylinositol 3-kinase signaling GO:0016458 gene silencing GO:0016575 histone deacetylation GO:0021762 substantia nigra development GO:0022011 myelination in peripheral nervous system GO:0030154 cell differentiation GO:0031641 regulation of myelination GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0034599 cellular response to oxidative stress GO:0034983 peptidyl-lysine deacetylation GO:0035729 cellular response to hepatocyte growth factor stimulus GO:0042177 negative regulation of protein catabolic process GO:0042325 regulation of phosphorylation GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043388 positive regulation of DNA binding GO:0043491 protein kinase B signaling GO:0044242 cellular lipid catabolic process GO:0045087 innate immune response GO:0045598 regulation of fat cell differentiation GO:0045599 negative regulation of fat cell differentiation GO:0045836 positive regulation of meiotic nuclear division GO:0045843 negative regulation of striated muscle tissue development GO:0045892 negative regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048012 hepatocyte growth factor receptor signaling pathway GO:0051301 cell division GO:0051321 meiotic cell cycle GO:0051726 regulation of cell cycle GO:0051775 response to redox state GO:0051781 positive regulation of cell division GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061433 cellular response to caloric restriction GO:0070446 negative regulation of oligodendrocyte progenitor proliferation GO:0070932 histone H3 deacetylation GO:0070933 histone H4 deacetylation GO:0071219 cellular response to molecule of bacterial origin GO:0071456 cellular response to hypoxia GO:0071872 cellular response to epinephrine stimulus GO:0090042 tubulin deacetylation GO:1900119 positive regulation of execution phase of apoptosis GO:1900195 positive regulation of oocyte maturation GO:1900226 negative regulation of NLRP3 inflammasome complex assembly GO:1900425 negative regulation of defense response to bacterium GO:2000378 negative regulation of reactive oxygen species metabolic process GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
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