Human Gene NFKBIB (ENST00000313582.6) from GENCODE V44
Description: Homo sapiens NFKB inhibitor beta (NFKBIB), transcript variant 1, mRNA. (from RefSeq NM_002503) RefSeq Summary (NM_002503): The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]. Gencode Transcript: ENST00000313582.6 Gencode Gene: ENSG00000104825.17 Transcript (Including UTRs) Position: hg38 chr19:38,899,969-38,908,889 Size: 8,921 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr19:38,900,033-38,908,832 Size: 8,800 Coding Exon Count: 6
ID:IKBB_HUMAN DESCRIPTION: RecName: Full=NF-kappa-B inhibitor beta; Short=NF-kappa-BIB; AltName: Full=I-kappa-B-beta; Short=IkB-B; Short=IkB-beta; Short=IkappaBbeta; AltName: Full=Thyroid receptor-interacting protein 9; Short=TR-interacting protein 9; Short=TRIP-9; FUNCTION: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. SUBUNIT: Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2. INTERACTION: Q04206:RELA; NbExp=6; IntAct=EBI-352889, EBI-73886; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in all tissues examined. PTM: Phosphorylated; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. SIMILARITY: Belongs to the NF-kappa-B inhibitor family. SIMILARITY: Contains 6 ANK repeats. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/nfkbib/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15653
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system
Reactome (by CSHL, EBI, and GO)
Protein Q15653 (Reactome details) participates in the following event(s):
R-HSA-168140 Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex R-HSA-1168638 Activated IKK phosphorylates I-kappaB R-HSA-1168642 SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-933542 TRAF6 mediated NF-kB activation R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975871 MyD88 cascade initiated on plasma membrane R-HSA-9020702 Interleukin-1 signaling R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs R-HSA-1169091 Activation of NF-kappaB in B cells R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168898 Toll-Like Receptors Cascades R-HSA-166166 MyD88-independent TLR4 cascade R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-446652 Interleukin-1 family signaling R-HSA-168249 Innate Immune System R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-449147 Signaling by Interleukins R-HSA-168256 Immune System R-HSA-983705 Signaling by the B Cell Receptor (BCR) R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System
US Server
