Human Gene DYRK1B (ENST00000348817.7) from GENCODE V44
Description: Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 3, mRNA. (from RefSeq NM_006484) RefSeq Summary (NM_006484): This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]. Gencode Transcript: ENST00000348817.7 Gencode Gene: ENSG00000105204.14 Transcript (Including UTRs) Position: hg38 chr19:39,825,353-39,834,201 Size: 8,849 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr19:39,825,715-39,831,867 Size: 6,153 Coding Exon Count: 11
ID:DYR1B_HUMAN DESCRIPTION: RecName: Full=Dual specificity tyrosine-phosphorylation-regulated kinase 1B; EC=2.7.12.1; AltName: Full=Minibrain-related kinase; AltName: Full=Mirk protein kinase; FUNCTION: Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Inhibited by RANBP9. SUBUNIT: Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with DCAF7. INTERACTION: P20823:HNF1A; NbExp=4; IntAct=EBI-634187, EBI-636034; P46734:MAP2K3; NbExp=2; IntAct=EBI-634187, EBI-602462; Q9H0N5:PCBD2; NbExp=2; IntAct=EBI-634187, EBI-634289; Q96S59:RANBP9; NbExp=4; IntAct=EBI-634187, EBI-636085; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. PTM: Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization. SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAC28914.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/DYRK1BID43235ch19q13.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y463
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
