Human Gene PSMC4 (ENST00000157812.7) from GENCODE V44
Description: Homo sapiens proteasome 26S subunit, ATPase 4 (PSMC4), transcript variant 1, mRNA. (from RefSeq NM_006503) RefSeq Summary (NM_006503): The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]. Gencode Transcript: ENST00000157812.7 Gencode Gene: ENSG00000013275.8 Transcript (Including UTRs) Position: hg38 chr19:39,971,165-39,981,764 Size: 10,600 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr19:39,971,203-39,981,305 Size: 10,103 Coding Exon Count: 11
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P43686
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001824 blastocyst development GO:0006508 proteolysis GO:0016579 protein deubiquitination GO:0030163 protein catabolic process GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0043687 post-translational protein modification GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:1901800 positive regulation of proteasomal protein catabolic process