Human Gene PLD3 (uc002ono.3) Description and Page Index
Description: Homo sapiens phospholipase D family, member 3 (PLD3), transcript variant 1, mRNA. RefSeq Summary (NM_001031696): This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]. Transcript (Including UTRs) Position: hg19 chr19:40,872,326-40,873,751 Size: 1,426 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chr19:40,872,391-40,872,813 Size: 423 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.