Human Gene PSG8 (ENST00000404209.8) from GENCODE V44
Description: Homo sapiens pregnancy specific beta-1-glycoprotein 8 (PSG8), transcript variant 2, mRNA. (from RefSeq NM_001130167) RefSeq Summary (NM_001130167): The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]. Gencode Transcript: ENST00000404209.8 Gencode Gene: ENSG00000124467.20 Transcript (Including UTRs) Position: hg38 chr19:42,752,686-42,765,678 Size: 12,993 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr19:42,753,360-42,765,581 Size: 12,222 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UQ74
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Cellular Component: GO:0005576 extracellular region
Descriptions from all associated GenBank mRNAs
CU676704 - Synthetic construct Homo sapiens gateway clone IMAGE:100022294 5' read PSG9 mRNA. BC142628 - Homo sapiens pregnancy specific beta-1-glycoprotein 8, mRNA (cDNA clone MGC:164802 IMAGE:40147510), complete cds. AK092458 - Homo sapiens cDNA FLJ35139 fis, clone PLACE6009482, weakly similar to Human gene for carcinoembryonic antigen subdomains A and B. M30629 - Human pregnancy-specific glycoprotein beta-1 (SP1) mRNA, last exon. CR749812 - Homo sapiens mRNA; cDNA DKFZp781L10202 (from clone DKFZp781L10202). JD352624 - Sequence 333648 from Patent EP1572962. AK300230 - Homo sapiens cDNA FLJ58622 complete cds, highly similar to Pregnancy-specific beta-1-glycoprotein 8 precursor. JD315521 - Sequence 296545 from Patent EP1572962. JD547533 - Sequence 528557 from Patent EP1572962. JD197598 - Sequence 178622 from Patent EP1572962. BC137500 - Homo sapiens pregnancy specific beta-1-glycoprotein 8, mRNA (cDNA clone MGC:169123 IMAGE:9021500), complete cds. KJ896276 - Synthetic construct Homo sapiens clone ccsbBroadEn_05670 PSG8 gene, encodes complete protein. JD447444 - Sequence 428468 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9UQ74 (Reactome details) participates in the following event(s):