Human Gene PSG8 (ENST00000404209.8) from GENCODE V44
  Description: Homo sapiens pregnancy specific beta-1-glycoprotein 8 (PSG8), transcript variant 2, mRNA. (from RefSeq NM_001130167)
RefSeq Summary (NM_001130167): The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009].
Gencode Transcript: ENST00000404209.8
Gencode Gene: ENSG00000124467.20
Transcript (Including UTRs)
   Position: hg38 chr19:42,752,686-42,765,678 Size: 12,993 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr19:42,753,360-42,765,581 Size: 12,222 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:42,752,686-42,765,678)mRNA (may differ from genome)Protein (419 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PSG8_HUMAN
DESCRIPTION: RecName: Full=Pregnancy-specific beta-1-glycoprotein 8; Short=PS-beta-G-8; Short=PSBG-8; Short=Pregnancy-specific glycoprotein 8; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
DEVELOPMENTAL STAGE: PSBG are produced in high quantity during pregnancy.
SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.17 RPKM in Testis
Total median expression: 0.22 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.5097-0.273 Picture PostScript Text
3' UTR -157.20674-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR013106 - Ig_V-set

Pfam Domains:
PF07686 - Immunoglobulin V-set domain

ModBase Predicted Comparative 3D Structure on Q9UQ74
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  CU676704 - Synthetic construct Homo sapiens gateway clone IMAGE:100022294 5' read PSG9 mRNA.
BC142628 - Homo sapiens pregnancy specific beta-1-glycoprotein 8, mRNA (cDNA clone MGC:164802 IMAGE:40147510), complete cds.
AK092458 - Homo sapiens cDNA FLJ35139 fis, clone PLACE6009482, weakly similar to Human gene for carcinoembryonic antigen subdomains A and B.
M30629 - Human pregnancy-specific glycoprotein beta-1 (SP1) mRNA, last exon.
CR749812 - Homo sapiens mRNA; cDNA DKFZp781L10202 (from clone DKFZp781L10202).
JD352624 - Sequence 333648 from Patent EP1572962.
AK300230 - Homo sapiens cDNA FLJ58622 complete cds, highly similar to Pregnancy-specific beta-1-glycoprotein 8 precursor.
JD315521 - Sequence 296545 from Patent EP1572962.
JD547533 - Sequence 528557 from Patent EP1572962.
JD197598 - Sequence 178622 from Patent EP1572962.
BC137500 - Homo sapiens pregnancy specific beta-1-glycoprotein 8, mRNA (cDNA clone MGC:169123 IMAGE:9021500), complete cds.
KJ896276 - Synthetic construct Homo sapiens clone ccsbBroadEn_05670 PSG8 gene, encodes complete protein.
JD447444 - Sequence 428468 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UQ74 (Reactome details) participates in the following event(s):

R-HSA-8870732 PSGs bind proteoglycans and TGF-beta1
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-109582 Hemostasis

-  Other Names for This Gene
  Alternate Gene Symbols: A5PKV3, B2RPL4, B4DTI6, ENST00000404209.1, ENST00000404209.2, ENST00000404209.3, ENST00000404209.4, ENST00000404209.5, ENST00000404209.6, ENST00000404209.7, NM_001130167, O60410, PSG8_HUMAN, Q68CR6, Q9UQ74, uc002ouh.1, uc002ouh.2, uc002ouh.3, uc002ouh.4
UCSC ID: ENST00000404209.8
RefSeq Accession: NM_001130167
Protein: Q9UQ74 (aka PSG8_HUMAN)
CCDS: CCDS33037.1, CCDS46091.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.